TSHR
促甲状腺激素受体（TSHR）是一种位于甲状腺滤泡细胞膜上的糖蛋白受体，全称为甲状腺刺激素受体。它负责感知促甲状腺激素（TSH）或自身抗体的结合，从而调控甲状腺激素（T3/T4）的合成与分泌。TSHR通过复杂的信号网络，在人体代谢、生长发育和能量平衡中发挥核心作用。近年来，TSHR被证实与多种自身免疫性甲状腺疾病及甲状腺癌密切相关，使其成为生物医药领域的研究热点。
TSHR的异常激活或失调与多种疾病有关。例如，Graves病患者体内产生自身抗体激活TSHR，导致甲状腺激素过量分泌和甲亢，并可能发展为Graves眼病，引起眼部肌肉肿胀。与之相反，桥本甲状腺炎患者体内存在阻断性抗体，抑制TSHR功能并引发甲状腺功能减退。此外，约80%的分化型甲状腺癌呈现TSHR过度表达，通过激活MAPK和PI3K/AKT通路促进肿瘤增殖及转移。基于TSHR的分子特性，放射性碘治疗已成功应用于甲状腺癌靶向治疗。
针对TSHR功能异常引发的疾病，已形成多维度靶向治疗格局。例如，CAR-T细胞疗法通过基因工程改造T细胞靶向TSHR，实现特异性杀伤；重组TSHR类药物如Thyrogen可增强甲状腺细胞摄碘能力，赛诺璟提升rhTSH半衰期，提高术后清甲成功率；单/双抗药物如GensSci098单抗降低游离T4水平并抑制眼眶成纤维细胞IL-6分泌，双抗药物VBS-102创新性构建TSHR和IGF-1R双靶点阻断机制，抑制多条通路活性，改善眼球突出。融合蛋白与基因疗法如VTC-G90降低甲状腺激素水平，基因编辑疗法缩小甲状腺体积，为治疗甲状腺相关疾病提供了新的方向。
热销产品
Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) (CSB-MP025131HU)
验证数据
CSB-MP025131HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TSHR at 10 μg/ml can bind Anti-TSHR recombinant antibody (CSB-RA025131MA1HU). The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 90% as determined by SEC-HPLC
Recombinant Human Thyrotropin receptor (TSHR), partial (CSB-BP025131HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TSHR Recombinant Monoclonal Antibody (CSB-RA025131MA1HU)
验证数据
The Binding Activity of Human TSHR with Anti-TSHR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSHR (CSB-MP025131HU) at 10 μg/mL can bind Anti-TSHR recombinant antibody. The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
Untransfected HEK293T cells (green line) and transfected Human TSHR HEK293T stable cells (red line) were stained with anti-TSHR antibody (CSB-RA025131MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The purity of TSHR was greater than 95% as determined by SEC-HPLC
TSHR Antibodies
TSHR for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA11189D0Rb | TSHR Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11189C0Rb | TSHR Antibody, FITC conjugated | Human | |
| CSB-PA11189B0Rb | TSHR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11189A0Rb | TSHR Antibody | Human | ELISA, IF |
| CSB-PA025131GA01HU | TSHR Antibody | Human,Mouse | ELISA,WB |
| CSB-PA973863 | TSHR Antibody | Human | ELISA,IHC |
| CSB-PA820027 | TSHR Antibody | Human | ELISA,IHC |
| CSB-RA025131MA1HU | TSHR Recombinant Monoclonal Antibody | Human | ELISA |
TSHR Proteins
TSHR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131DO1 CSB-EP025131DO1 CSB-BP025131DO1 CSB-MP025131DO1 CSB-EP025131DO1-B |
Recombinant Dog Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131DO | Recombinant Dog Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131RA1 CSB-EP025131RA1 CSB-BP025131RA1 CSB-MP025131RA1 CSB-EP025131RA1-B |
Recombinant Rat Thyrotropin receptor (Tshr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131RA | Recombinant Rat Thyrotropin receptor (Tshr) | in vitro E.coli expression system |
TSHR Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131MO CSB-EP025131MO CSB-EP025131MO-B |
Recombinant Mouse Thyrotropin receptor (Tshr), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Baculovirus |
| CSB-MP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Mammalian cell |
TSHR Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131SH1 CSB-EP025131SH1 CSB-BP025131SH1 CSB-MP025131SH1 CSB-EP025131SH1-B |
Recombinant Sheep Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131SH | Recombinant Sheep Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP631684BO1 CSB-EP631684BO1 CSB-BP631684BO1 CSB-MP631684BO1 CSB-EP631684BO1-B |
Recombinant Bovine Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF631684BO | Recombinant Bovine Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP819360PI CSB-EP819360PI CSB-BP819360PI CSB-MP819360PI CSB-EP819360PI-B |
Recombinant Pig Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TSHR Proteins for Felis catus (Cat) (Felis silvestris catus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP858993CA1 CSB-EP858993CA1 CSB-BP858993CA1 CSB-MP858993CA1 CSB-EP858993CA1-B |
Recombinant Cat Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF858993CA | Recombinant Cat Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-BP025131HU1 | Recombinant Human Thyrotropin receptor (TSHR), partial | Baculovirus |
| CSB-MP025131HU | Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) | Mammalian cell |
