TSHR
TSHR，即促甲状腺激素受体，别名Thyrotropinreceptor。它是一种细胞表面糖蛋白受体，属于A类G蛋白偶联受体（GPCRs）超家族的LGR亚家族，并与Gs蛋白相连接。TSHR主要在甲状腺组织中表达，但其mRNA和蛋白也存在于神经组织、免疫细胞、眼肌、骨骼、脂肪细胞、红细胞、卵巢和肝脏等部位。TSHR的作用机制是通过其受体感知由垂体细胞分泌的促甲状腺激素（TSH）信号，启动偶联信号通路，促进下游效应基因的表达，刺激细胞生成甲状腺激素（T4）和三碘甲状腺激素（T3），对甲状腺的生长和功能至关重要。TSHR的异常激活或失调与多种疾病有关，如Graves病（GD）患者产生自身抗体激活TSHR，导致甲亢，并可能发展为Graves眼病（GO），引起眼部肌肉肿胀。TSHR功能失调也会影响甲状腺激素生成，引发甲减。桥本病（Hashimoto'sdisease）患者产生抑制TSHR的抗体，可导致甲状腺功能减退。TSHR的表达在某些甲状腺结节和癌症中的变化可以作为诊断和预后的指标。
热销产品
Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) (CSB-MP025131HU)
验证数据
CSB-MP025131HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TSHR at 10 μg/ml can bind Anti-TSHR recombinant antibody (CSB-RA025131MA1HU). The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 90% as determined by SEC-HPLC
TSHR Recombinant Monoclonal Antibody (CSB-RA025131MA1HU)
验证数据
The Binding Activity of Human TSHR with Anti-TSHR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSHR (CSB-MP025131HU) at 10 μg/mL can bind Anti-TSHR recombinant antibody. The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
Untransfected HEK293T cells (green line) and transfected Human TSHR HEK293T stable cells (red line) were stained with anti-TSHR antibody (CSB-RA025131MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The purity of TSHR was greater than 95% as determined by SEC-HPLC
TSHR Antibodies
TSHR for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA11189D0Rb | TSHR Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11189C0Rb | TSHR Antibody, FITC conjugated | Human | |
| CSB-PA11189B0Rb | TSHR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11189A0Rb | TSHR Antibody | Human | ELISA, IF |
| CSB-PA025131GA01HU | TSHR Antibody | Human,Mouse | ELISA,WB |
| CSB-PA973863 | TSHR Antibody | Human | ELISA,IHC |
| CSB-PA820027 | TSHR Antibody | Human | ELISA,IHC |
| CSB-RA025131MA1HU | TSHR Recombinant Monoclonal Antibody | Human | ELISA |
TSHR Proteins
TSHR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131DO1 CSB-EP025131DO1 CSB-BP025131DO1 CSB-MP025131DO1 CSB-EP025131DO1-B |
Recombinant Dog Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131DO | Recombinant Dog Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131RA1 CSB-EP025131RA1 CSB-BP025131RA1 CSB-MP025131RA1 CSB-EP025131RA1-B |
Recombinant Rat Thyrotropin receptor (Tshr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131RA | Recombinant Rat Thyrotropin receptor (Tshr) | in vitro E.coli expression system |
TSHR Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131MO CSB-EP025131MO CSB-EP025131MO-B |
Recombinant Mouse Thyrotropin receptor (Tshr), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Baculovirus |
| CSB-MP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Mammalian cell |
TSHR Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025131SH1 CSB-EP025131SH1 CSB-BP025131SH1 CSB-MP025131SH1 CSB-EP025131SH1-B |
Recombinant Sheep Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131SH | Recombinant Sheep Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP631684BO1 CSB-EP631684BO1 CSB-BP631684BO1 CSB-MP631684BO1 CSB-EP631684BO1-B |
Recombinant Bovine Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF631684BO | Recombinant Bovine Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP819360PI CSB-EP819360PI CSB-BP819360PI CSB-MP819360PI CSB-EP819360PI-B |
Recombinant Pig Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TSHR Proteins for Felis catus (Cat) (Felis silvestris catus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP858993CA1 CSB-EP858993CA1 CSB-BP858993CA1 CSB-MP858993CA1 CSB-EP858993CA1-B |
Recombinant Cat Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF858993CA | Recombinant Cat Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-BP025131HU1 | Recombinant Human Thyrotropin receptor (TSHR), partial | Baculovirus |
| CSB-MP025131HU | Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) | Mammalian cell |
