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TPBG

TPBG,即滋养层糖蛋白,别名5T4和WAIF1。它是一种由TPBG基因编码的跨膜糖蛋白,首次在人胎盘组织中发现。TPBG在多种癌细胞中过度表达,与肿瘤的侵袭、转移和预后密切相关。其作用机制涉及作为Wnt/β-catenin信号通路的拮抗剂,通过抑制LRP6与Wnt受体的内吞来阻断信号传导,从而抑制细胞粘附和细胞骨架的形成,促进肿瘤细胞的迁移和扩散。TPBG的异常表达与多种癌症的发展有关,使其成为肿瘤治疗的潜在靶点,靶向TPBG的药物开发正在积极探索中。

热销产品

Recombinant Human Trophoblast glycoprotein (TPBG), partial (Active) (CSB-MP024093HUb0)

验证数据

CSB-MP024093HUb0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP024093HUb0

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TPBG at 2 μg/mL can bind Anti-TPBG recombinant antibody (CSB-RA024093MA1HU), the EC50 is 1.230-1.519 ng/mL.

TPBG Recombinant Monoclonal Antibody (CSB-RA024093MA1HU)

验证数据

CSB-RA024093MA1HU

The Binding Activity of TPBG with Anti-TPBG monoclonal antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TPBG (CSB-MP024093HUB0) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.230-1.519 ng/mL.

CSB-RA024093MA1HU

The Binding Activity of Macaca fascicularis TPBG with Anti-TPBG monoclonal antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis TPBG (CSB-MP024093MOV) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.672-2.181 ng/mL.

TPBG Antibodies

TPBG for Rattus norvegicus (Rat)

TPBG for Homo sapiens (Human)

TPBG Proteins

TPBG Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

TPBG Proteins for Rattus norvegicus (Rat)

TPBG Proteins for Homo sapiens (Human)