TPBG
TPBG,即滋养层糖蛋白,别名5T4和WAIF1。它是一种由TPBG基因编码的跨膜糖蛋白,首次在人胎盘组织中发现。TPBG在多种癌细胞中过度表达,与肿瘤的侵袭、转移和预后密切相关。其作用机制涉及作为Wnt/β-catenin信号通路的拮抗剂,通过抑制LRP6与Wnt受体的内吞来阻断信号传导,从而抑制细胞粘附和细胞骨架的形成,促进肿瘤细胞的迁移和扩散。TPBG的异常表达与多种癌症的发展有关,使其成为肿瘤治疗的潜在靶点,靶向TPBG的药物开发正在积极探索中。
热销产品
Recombinant Human Trophoblast glycoprotein (TPBG), partial (Active) (CSB-MP024093HUb0)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TPBG at 2 μg/mL can bind Anti-TPBG recombinant antibody (CSB-RA024093MA1HU), the EC50 is 1.230-1.519 ng/mL.
TPBG Recombinant Monoclonal Antibody (CSB-RA024093MA1HU)
验证数据
The Binding Activity of TPBG with Anti-TPBG monoclonal antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TPBG (CSB-MP024093HUB0) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.230-1.519 ng/mL.
The Binding Activity of Macaca fascicularis TPBG with Anti-TPBG monoclonal antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis TPBG (CSB-MP024093MOV) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.672-2.181 ng/mL.
TPBG Antibodies
TPBG for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA024093LA01RA | Tpbg Antibody | Rat | ELISA |
CSB-PA024093LB01RA | Tpbg Antibody, HRP conjugated | Rat | ELISA |
TPBG for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-RA669019A0HU | TPBG Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA902876A0HU | TPBG Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC |
CSB-RA024093MA1HU | TPBG Recombinant Monoclonal Antibody | Human, Macaca mulatta | ELISA |
CSB-RA024093MA2HU | TPBG Recombinant Monoclonal Antibody | Human | ELISA, FC |
TPBG Proteins
TPBG Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP024093MOV | Recombinant Macaca fascicularis Trophoblast glycoprotein (TPBG), partial | Yeast |
CSB-EP024093MOV | Recombinant Macaca fascicularis Trophoblast glycoprotein (TPBG), partial | E.coli |
CSB-BP024093MOV CSB-EP024093MOV-B |
Recombinant Macaca fascicularis Trophoblast glycoprotein (TPBG), partial | Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP024093MOV | Recombinant Macaca fascicularis Trophoblast glycoprotein (TPBG), partial (Active) | Mammalian cell |
TPBG Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP024093RA CSB-BP024093RA CSB-MP024093RA CSB-EP024093RA-B |
Recombinant Rat Trophoblast glycoprotein (Tpbg), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP024093RA | Recombinant Rat Trophoblast glycoprotein (Tpbg), partial | E.coli |
TPBG Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP024093HU CSB-EP024093HU CSB-BP024093HU CSB-EP024093HU-B |
Recombinant Human Trophoblast glycoprotein (TPBG), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP024093HUb0 | Recombinant Human Trophoblast glycoprotein (TPBG), partial (Active) | Mammalian cell |
CSB-MP024093HU | Recombinant Human Trophoblast glycoprotein (TPBG) | Mammalian cell |