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TP53

TP53,即肿瘤蛋白p53,别名CC7、Cellular tumor antigen p53、LFS1、Mutant tumor protein 53、p53。它是一种由TP53基因编码的转录因子,位于人类第17号染色体上,是细胞周期的关键调控因子。TP53的作用机制主要是通过响应细胞应激反应,如DNA损伤、缺氧、代谢应激等,调节多种下游基因的表达,从而诱导细胞周期停滞、凋亡、衰老、DNA修复或代谢变化。TP53参与了细胞周期的调控、DNA损伤修复、细胞凋亡和衰老等过程,被广泛认为是“基因组的卫士”。TP53的突变与多种人类癌症的发生发展有关,包括遗传性癌症如Li-Fraumeni综合征。此外,TP53还调节细胞代谢、铁死亡、肿瘤微环境、自噬等,这些都有助于肿瘤抑制。TP53的突变不仅损害其抑癌功能,而且还可能赋予p53突变体致癌特性,使其成为开发新抗癌药物的一个非常有吸引力的靶点 。

热销产品

Recombinant Human Cellular tumor antigen p53 (TP53) (CSB-BP024077HU)

验证数据

CSB-BP024077HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TP53 Recombinant Monoclonal Antibody (CSB-RA236796A0HU)

验证数据

CSB-RA236796A0HU

Western Blot
Positive WB detected in: COLO320 whole cell lysate, 293 whole cell lysate
All lanes: TP53 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44, 38, 39, 40, 34, 35, 30, 24, 25 kDa
Observed band size: 53 kDa

CSB-RA236796A0HU

IHC image of CSB-RA236796A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA236796A0HU

Immunofluorescence staining of HepG2 Cells with CSB-RA236796A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Human p53/tumor protein,p53/TP53 ELISA Kit (CSB-E08334h)

验证数据

CSB-E08334h 标准曲线

货号:CSB-E08334h

规格:96T/48T

灵敏度:2.34 pg/mL

检测范围:9.38 pg/mL-600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TP53 Antibodies

TP53 for Rattus norvegicus (Rat)

TP53 for Homo sapiens (Human)

TP53 for Mus musculus (Mouse)

TP53 for H

TP53 for H,R,M

TP53 Proteins

TP53 Proteins for Equus caballus (Horse)

TP53 Proteins for Bos taurus (Bovine)

TP53 Proteins for Gallus gallus (Chicken)

TP53 Proteins for Felis catus (Cat) (Felis silvestris catus)

TP53 Proteins for Ovis aries (Sheep)

TP53 Proteins for Macaca mulatta (Rhesus macaque)

TP53 Proteins for Homo sapiens (Human)

TP53 Proteins for Mus musculus (Mouse)

TP53 Proteins for Bos indicus (Zebu)

TP53 Proteins for Oryzias latipes (Medaka fish) (Japanese ricefish)

TP53 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

TP53 Proteins for Rattus norvegicus (Rat)

TP53 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

TP53 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

TP53 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

TP53 Proteins for Macaca fuscata fuscata (Japanese macaque)

TP53 Proteins for Xenopus laevis (African clawed frog)

TP53 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

TP53 Proteins for Platichthys flesus (European flounder) (Pleuronectes flesus)

TP53 Proteins for Marmota monax (Woodchuck)

TP53 Proteins for Xiphophorus helleri (Green swordtail)

TP53 Proteins for Ictalurus punctatus (Channel catfish)

TP53 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

TP53 Proteins for Equus asinus (Donkey)

TP53 Proteins for Spermophilus beecheyi (Beechey ground squirrel) (Otospermophilus beecheyi)

TP53 Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)

TP53 Proteins for Delphinapterus leucas (Beluga whale)

TP53 Proteins for Oryctolagus cuniculus (Rabbit)

TP53 Proteins for Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri)

TP53 Proteins for Sus scrofa (Pig)

TP53 Proteins for Cavia porcellus (Guinea pig)

TP53 Proteins for Barbus barbus (Barbel)

TP53 Proteins for Tetraodon miurus (Congo puffer)

TP53 ELISA Kit

TP53 ELISA Kit for Homo sapiens (Human)