TNFRSF9
TNFRSF9,即肿瘤坏死因子受体超家族成员9,别名CD137、4-1BB,是一种I型跨膜蛋白,属于肿瘤坏死因子受体超家族,主要表达于活化的T细胞表面,也在B细胞、单核细胞和多种转化细胞系中有表达。
TNFRSF9蛋白与配体4-1BBL(TNFSF9)结合,激活下游的NF-κB信号通路,促进T细胞的克隆增殖、存活和发育。TNFRSF9在免疫应答中发挥关键作用,特别是在增强T细胞介导的免疫反应和调节细胞毒性T细胞的活性方面。
TNFRSF9的表达还与多种疾病相关,包括自身免疫疾病和肿瘤等,是免疫治疗的潜在靶点。
热销产品
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFRSF9 at 2 μg/ml can bind TNFSF9(CSB-MP023997HU1), the EC50 is 1.011-2.429 ng/mL.
TNFRSF9 Antibody (CSB-PA08109A0Rb)
验证数据

Western Blot
Positive WB detected in: HepG2 whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate
All lanes: TNFRSF9 antibody at 2.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 65 kDa

Immunofluorescent analysis of A549 cells using CSB-PA08109A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TNFRSF9 Antibodies
TNFRSF9 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA011218 | TNFRSF9 Antibody | Human | WB, IF, ELISA |
CSB-PA983768 | TNFRSF9 Antibody | Human | ELISA,IHC |
CSB-PA718806 | TNFRSF9 Antibody | Human | IHC,ELISA |
CSB-PA08109A0Rb | TNFRSF9 Antibody | Human | ELISA, WB, IF |
CSB-PA08109B0Rb | TNFRSF9 Antibody, HRP conjugated | Human | ELISA |
CSB-PA08109C0Rb | TNFRSF9 Antibody, FITC conjugated | Human | |
CSB-PA08109D0Rb | TNFRSF9 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA023984A1HU | TNFRSF9/4-1BB Recombinant Monoclonal Antibody | Human | ELISA |
TNFRSF9 Proteins
TNFRSF9 Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP023984MO1 CSB-EP023984MO1 CSB-BP023984MO1 CSB-MP023984MO1 CSB-EP023984MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 9 (Tnfrsf9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF023984MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 9 (Tnfrsf9) | in vitro E.coli expression system |
TNFRSF9 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-AP001951HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 protein (TNFRSF9), partial | E.Coli |
CSB-AP005131HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
CSB-AP005141HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
CSB-AP005151HU | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
CSB-MP023984HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active) | Mammalian cell |
TNFRSF9 ELISA Kit
TNFRSF9 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL023984HU | Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9) ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
TNFRSF9 ELISA Kit for Mus musculus (Mouse)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL023984MO | Mouse Tumor necrosis factor receptor superfamily member 9(TNFRSF9) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/ml |