ROR1
ROR1,即受体酪氨酸激酶样孤儿受体1,别名Neurotrophic tyrosine kinase, receptor-related 1。它是一种I型跨膜蛋白,属于受体酪氨酸激酶(RTKs)家族成员之一。ROR1在人正常组织中低表达或不表达,但在多种恶性肿瘤或组织中高度表达,如慢性淋巴细胞白血病(CLL)、乳腺癌、卵巢癌、黑色素瘤、肺腺癌等。ROR1的作用机制涉及介导非经典的Wnt信号通路,尤其是Wnt5a,参与NF-κB亚基p65的磷酸化,激活肿瘤细胞中NF-κB通路,促进细胞迁移和侵袭。作为一种具有高度识别性的肿瘤特异性标志物,ROR1已成为肿瘤治疗中一个潜在极具吸引力的靶点。
热销产品
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized ROR1 at 2 μg/ml can bind anti-ROR1 antibody(CSB-RA020067A1HU), the EC50 is 0.2450-0.3416 ng/mL.

The purity of ROR1 was greater than 90% as determined by SEC-HPLC
ROR1 Recombinant Monoclonal Antibody (CSB-RA020067A1HU)
验证数据

The Binding Activity of ROR1 with Anti-ROR1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ROR1(CSB-MP020067HU1d7) at 2 μg/mL can bind Anti-ROR1 recombinant antibody, the EC50 is 0.2450-0.3416 ng/mL.

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
ROR1 Antibodies
ROR1 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA020067LC01HU | ROR1 Antibody, FITC conjugated | Human | |
CSB-PA020067GA01HU | ROR1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA067964 | ROR1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA993257 | ROR1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA020067LA01HU | ROR1 Antibody | Human | ELISA, IHC |
CSB-RA020067A1HU | ROR1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
ROR1 Proteins
ROR1 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP020067HU | Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial | Yeast |
CSB-EP020067HU | Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial | E.coli |
CSB-MP020067HU1d7 | Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial (Active) | Mammalian cell |