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ROR1

ROR1,全称受体酪氨酸激酶样孤儿受体1,常见别名包括Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1)等。该蛋白在正常组织中低表达或不表达,但在多种恶性肿瘤中高表达,如慢性淋巴细胞白血病、乳腺癌、卵巢癌、黑色素瘤、肺腺癌等。ROR1蛋白属于I型膜蛋白,具有酪氨酸激酶活性,参与细胞增殖、分化、迁移等过程。研究表明,ROR1蛋白与肿瘤细胞的生长和转移密切相关,是肿瘤治疗的重要靶点。目前,针对ROR1蛋白的药物研发正在积极进行中,包括抗体偶联药物(ADC)、单克隆抗体、双特异性抗体以及CAR-T疗法等多种类型。其中,华东医药研发的ROR1 ADC创新药注射用HDM2005已获得美国FDA孤儿药资格认定,显示出良好的临床前景。此外,石药集团、默沙东等药企也在积极布局ROR1靶点药物的研发,预计未来将有更多疗效显著、安全性高的ROR1靶向药物面世,为肿瘤患者带来新的治疗选择。

热销产品

Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial (Active) (CSB-MP020067HU1d7)

验证数据

CSB-MP020067HU1d7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP020067HU1d7

Activity
Measured by its binding ability in a functional ELISA. Immobilized ROR1 at 2 μg/ml can bind anti-ROR1 antibody(CSB-RA020067A1HU), the EC50 is 0.2450-0.3416 ng/mL.

CSB-MP020067HU1d7

The purity of ROR1 was greater than 90% as determined by SEC-HPLC

ROR1 Recombinant Monoclonal Antibody (CSB-RA020067A1HU)

验证数据

CSB-RA020067A1HU

The Binding Activity of ROR1 with Anti-ROR1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ROR1(CSB-MP020067HU1d7) at 2 μg/mL can bind Anti-ROR1 recombinant antibody, the EC50 is 0.2450-0.3416 ng/mL.

CSB-RA020067A1HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

ROR1 Antibody (CSB-PA020067LA01HU)

验证数据

CSB-PA020067LA01HU

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA020067LA01HU at dilution of 1:10

ROR1 Antibodies

ROR1 for Homo sapiens (Human)