PIK3CA

PIK3CA，即磷脂酰肌醇4,5-二磷酸3-激酶催化亚基α，别名PI3K-alpha。PIK3CA由人类PIK3CA基因编码，该基因位于3号染色体的q26.3区域，包含21个外显子，编码1068种氨基酸，产生一组长124kD的蛋白。PIK3CA的作用机制涉及催化膜脂磷脂酰肌醇-4,5-二磷酸[PI(4,5)P2]到第二信使PI(3,4,5)P3（也被称为PIP3）的转化，激活AKT-mTOR信号通路，促进细胞存活、增殖、生长和运动。PIK3CA是癌症中最常见的突变基因之一，其激活突变在乳腺癌、子宫内膜癌、膀胱癌、结肠直肠癌等多种癌症中均有发现，参与肿瘤发生、进展及转移定植。PIK3CA基因的突变导致PI3K/AKT通路水平上调，进而参与肿瘤发生。

热销产品

Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA), partial (CSB-EP017998HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PIK3CA Recombinant Monoclonal Antibody (CSB-RA578819A0HU)

验证数据

Western Blot
Positive WB detected in: Jurkat whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate
All lanes: PIK3CA antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 125 kDa
Observed band size: 110 kDa

Immunofluorescence staining of Hela Cells with CSB-RA578819A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

PIK3CA Antibody

PIK3CA Protein

PIK3CA ELISA Kit

PIK3CA Antibodies

PIK3CA for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA017998GA01HU	PIK3CA Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA003761	PIK3CA Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA017998LA01HU	PIK3CA Antibody	Human	ELISA, IHC, IF
CSB-PA017998LC01HU	PIK3CA Antibody, FITC conjugated	Human
CSB-PA017998LD01HU	PIK3CA Antibody, Biotin conjugated	Human	ELISA
CSB-RA578819A0HU	PIK3CA Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB, IF

PIK3CA Proteins

PIK3CA Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP017998BO CSB-EP017998BO CSB-BP017998BO CSB-MP017998BO CSB-EP017998BO-B	Recombinant Bovine Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PIK3CA Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP017998HU CSB-BP017998HU CSB-MP017998HU CSB-EP017998HU-B	Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP017998HU	Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA), partial	E.coli

PIK3CA Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP017998MO CSB-EP017998MO CSB-BP017998MO CSB-MP017998MO CSB-EP017998MO-B	Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Pik3ca), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli