NECTIN2
NECTIN2，全称为Nectin-2，也被称为CD112、HVEB、PVRL2，是一种参与细胞连接和信号传导的重要蛋白。它作为细胞粘附分子，在细胞间相互作用中发挥关键作用，并与某些病毒（如单纯疱疹病毒）的感染相关。NECTIN2蛋白在免疫细胞和其他类型细胞间的相互作用中影响细胞迁移和组织稳态，同时也在癌症和病毒感染等多种疾病中发挥作用。目前，针对NECTIN2的药物研发主要集中在癌症治疗领域，已有多个靶向NECTIN2的药物处于研发阶段。例如，橙帆医药与Avenzo Therapeutics达成了全球战略合作协议，共同研发和商业化一种Nectin4-TROP2双抗ADC药物，旨在治疗晚期实体瘤。此外，NECTIN2蛋白还与乳腺癌和卵巢癌等疾病相关，使其成为抗体治疗的潜在靶点。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis NECTIN2 at 2 μg/ml can bind Anti-NECTIN2 recombinant antibody(CSB-RA835690MA1HU). The EC50 is 1.011-1.193 ng/mL.
The purity of NECTIN2 was greater than 95% as determined by SEC-HPLC
Recombinant Human Nectin-2 (NECTIN2), partial (CSB-MP835690HUd7)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NECTIN2 Antibody (CSB-PA835690LA01HU)
验证数据
Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate
All lanes: NECTIN2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58, 52 kDa
Observed band size: 58 kDa
NECTIN2 Antibodies
NECTIN2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA019096GA01HU | PVRL2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006259 | PVRL2 Antibody | Human | WB, ELISA |
| CSB-PA163325 | PVRL2 Antibody | Human | ELISA,IHC |
| CSB-PA835690LA01HU | NECTIN2 Antibody | Human | ELISA, WB |
| CSB-PA835690LB01HU | NECTIN2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA835690LC01HU | NECTIN2 Antibody, FITC conjugated | Human |
NECTIN2 Proteins
NECTIN2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP019096MO1 CSB-EP019096MO1 CSB-BP019096MO1 CSB-MP019096MO1 CSB-EP019096MO1-B |
Recombinant Mouse Poliovirus receptor-related protein 2 (Pvrl2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF019096MO | Recombinant Mouse Nectin-2 (Nectin2) | in vitro E.coli expression system |
NECTIN2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP835690HU CSB-BP835690HU CSB-MP835690HU CSB-EP835690HU-B |
Recombinant Human Poliovirus receptor-related protein 2 (PVRL2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP835690HU | Recombinant Human Nectin-2 (PVRL2), partial | E.coli |
| CSB-AP005081HU | Recombinant Human Nectin-2 (NECTIN2), partial (Active) | Mammalian cell |
