MSLN
MSLN，即间皮素（Mesothelin），是一种糖基磷脂酰肌醇(GPI)锚定的细胞表面糖蛋白，由MSLN基因编码的前蛋白经过蛋白水解后产生巨核细胞增强因子和间皮素两种蛋白产物。
MSLN的作用机制涉及其在细胞表面的表达，通过与配体如CA125/MUC16的高亲和力相互作用促进异型细胞粘附，进而影响肿瘤的转移。此外，MSLN的过表达能够激活NF-κB、MAPK和PI3K-激酶促进细胞增殖和抵抗凋亡的细胞内通路。MSLN在正常组织中的表达有限，但在卵巢癌、乳腺癌、结直肠癌和胰腺癌等几种实体肿瘤中的过度表达，与较低的存活率相关，是肿瘤特异性治疗的理想靶点。
热销产品
Recombinant Human Mesothelin (MSLN), partial (Active) (CSB-MP015044HUc9)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/ml.
Activity
Measured by its binding ability in a functional ELISA. Immobilized MUC16(CSB-MP704410HU3c7) at 10 μg/ml can bind MSLN, the EC50 is 460.7-662.2 ng/ml.
MSLN Antibody (CSB-PA015044ESR1HU)
验证数据
Western blot
All lanes: MSLN antibody at 8µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 69, 72, 68 kDa
Observed band size: 69 kDa
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA015044ESR1HU at dilution of 1:100
MSLN Antibodies
MSLN for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA015044LA01MO | Msln Antibody | Mouse | ELISA |
| CSB-PA015044LB01MO | Msln Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA015044LC01MO | Msln Antibody, FITC conjugated | Mouse | |
| CSB-PA015044LD01MO | Msln Antibody, Biotin conjugated | Mouse | ELISA |
MSLN for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA10159A0Rb | MSLN Antibody | Human | ELISA, IHC, IF, IP |
| CSB-PA10159B0Rb | MSLN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA10159C0Rb | MSLN Antibody, FITC conjugated | Human | |
| CSB-PA10159D0Rb | MSLN Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA015044ESR1HU | MSLN Antibody | Human | ELISA, WB, IHC |
| CSB-PA015044ESR2HU | MSLN Antibody | Human | ELISA, IHC |
| CSB-PA846777 | MSLN Antibody | Human | ELISA,IHC |
| CSB-PA952111 | MSLN Antibody | Human | ELISA,IHC |
MSLN Proteins
MSLN Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015044MO | Recombinant Mouse Mesothelin (Msln), partial | Yeast |
| CSB-EP015044MO | Recombinant Mouse Mesothelin (Msln), partial | E.coli |
| CSB-BP015044MO CSB-MP015044MO CSB-EP015044MO-B |
Recombinant Mouse Mesothelin (Msln), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MSLN Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP015044RA CSB-EP015044RA CSB-BP015044RA CSB-MP015044RA CSB-EP015044RA-B |
Recombinant Rat Mesothelin (Msln) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MSLN Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-MP015044HU | Recombinant Human Mesothelin (MSLN), partial | Mammalian cell |
| CSB-MP015044HUf3 | Recombinant Human Mesothelin (MSLN), partial | Mammalian cell |
| CSB-MP015044HUc9 | Recombinant Human Mesothelin (MSLN), partial (Active) | Mammalian cell |
| CSB-MP015044HU-B | Recombinant Human Mesothelin (MSLN), partial,Biotinylated | Mammalian cell |
MSLN ELISA Kit
MSLN ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E13382h | Human Mesothelin(MSLN)ELISA KIT | serum, plasma, tissue homogenates | 15.6 pg/mL |
