MS4A1
MS4A1基因编码CD20蛋白,该抗原为一种疏水性4次跨膜蛋白,分子量大约为35kDa。CD20也叫B淋巴细胞表面抗原B1、Bp35、白细胞表面抗原Leu-16等等。CD20只在B淋巴细胞上表达,参与调节B细胞活化和增殖,作为钙离子通道发挥作用。除在正常B细胞中表达外,CD20还在B细胞来源的淋巴瘤、白血病等的肿瘤细胞表达,以及涉及免疫疾病和炎症疾病的B细胞中表达,所以CD20抗原成为淋巴癌、白血病和某些自体免疫等疾病治疗的目标靶点。目前,针对这些疾病的CD20治疗主要有三种方式,包括抗CD20单克隆抗体、CAR-T和双特异性抗体。自1997年全球首款抗CD20单抗——罗氏的利妥昔单抗获批以来,全球已经批准多款抗CD20单抗。相关数据统计显示,目前有高达90多种针对CD20的生物制剂处于临床开发阶段。
CUSABIO-哺乳包膜VLPs平台成功开发MS4A1全长膜蛋白(4次跨膜),展示了完整生物活性。
热销产品
● Recombinant Human B-lymphocyte antigen CD20(MS4A1)-VLPs (Active) CSB-MP015007HU
验证数据
CSB-MP015007HU is detected by Mouse anti-6*His monoclonal antibody.
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.
by TEM
The presence of VLP-like structures was confirmed by TEM.
● MS4A1 Recombinant Monoclonal Antibody CSB-RA015007MA4HU
验证数据
IHC image of CSB-RA015007MA4HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB
Immunofluorescence staining of Hela cell with CSB-RA015007MA4HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L)
Immunofluorescence staining of MCF7 cell with CSB-RA015007MA4HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L)
MS4A1 Antibodies
MS4A1 for Mus musculus (Mouse)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA015007LD01MO | Ms4a1 Antibody, Biotin conjugated | Mouse | ELISA |
CSB-PA015007LC01MO | Ms4a1 Antibody, FITC conjugated | Mouse | |
CSB-PA015007LB01MO | Ms4a1 Antibody, HRP conjugated | Mouse | ELISA |
CSB-PA015007LA01MO | Ms4a1 Antibody | Mouse, Human | ELISA, WB |
MS4A1 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA015007DSR2HU | MS4A1 Antibody | Human | ELISA, IHC |
CSB-PA001433 | MS4A1 Antibody | Human | WB, ELISA |
CSB-PA006161 | MS4A1 Antibody | Human | WB, ELISA |
CSB-RA015007A0HU | CD20 Recombinant Monoclonal Antibody | Human | ELISA |
CSB-MA996413 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA015007A1HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA |
CSB-RA015007MA3HU | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA |
CSB-RA015007MA4HU | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
MS4A1 for H, M, R
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-MA000204 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
MS4A1 Proteins
MS4A1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP661636DO1 CSB-BP661636DO1 CSB-MP661636DO1 CSB-EP661636DO1-B |
Recombinant Dog B-lymphocyte antigen CD20 (MS4A1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF661636DO | Recombinant Dog B-lymphocyte antigen CD20 (MS4A1) | in vitro E.coli expression system |
MS4A1 Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-EP015007MO2 | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | E.coli |
CSB-YP015007MO2 | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | Yeast |
CSB-YP015007MO1 | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | Yeast |
CSB-CF015007MO | Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1) | in vitro E.coli expression system |
CSB-BP015007MO2 CSB-MP015007MO2 CSB-EP015007MO2-B |
Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP015007MO1 CSB-BP015007MO1 CSB-MP015007MO1 CSB-EP015007MO1-B |
Recombinant Mouse B-lymphocyte antigen CD20 (Ms4a1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MS4A1 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP015007HU1 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | Yeast |
CSB-CF015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1) | in vitro E.coli expression system |
CSB-EP015007HU1 CSB-BP015007HU1 CSB-MP015007HU1 CSB-EP015007HU1-B |
Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP015007HU | Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) | Mammalian cell |
CSB-EP015007HU2 | Recombinant Human B-lymphocyte antigen CD20 (MS4A1), partial | E.coli |
MS4A1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-MP661636DO | Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) | Mammalian cell |
CSB-EP661636DO1 | Recombinant Canis lupus familiaris B-lymphocyte antigen CD20 (MS4A1), partial | E.coli |
MS4A1 ELISA Kit
MS4A1 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E14007h | Human B-lymphocyte antigen (CD20) ELISA Kit | serum, plasma, tissue homogenates | 0.78 ng/mL |