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Mitogen-activated protein kinase 3 is a protein in humans that is encoded by MAPK3 gene. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs.

MAPK3 Antibodies

MAPK3 for Homo sapiens (Human)

MAPK3 Proteins

MAPK3 Proteins for Rattus norvegicus (Rat)

MAPK3 Proteins for Homo sapiens (Human)

MAPK3 Proteins for Mus musculus (Mouse)