KMT2D
KMT2D，即赖氨酸甲基转移酶2D，别名MLL2、ALR、KABUKI综合症相关蛋白等。它是一种由KMT2D基因编码的酶，属于KMT2家族成员，在细胞核中发挥作用。KMT2D的作用机制主要是通过催化组蛋白H3赖氨酸4的单甲基化和双甲基化，参与调控基因表达和增强子活性。KMT2D参与了细胞增殖、分化、肿瘤发展等过程。KMT2D的功能异常与多种疾病有关，包括癌症、智力障碍、发育异常等。KMT2D在前列腺癌中通过调控特定基因表达，激活PI3K/AKT、EMT通路，促进肿瘤生长及转移。因此，KMT2D是肿瘤研究和治疗中的潜在靶点。
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验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA965267(KMT2D Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
KMT2D Antibodies
KMT2D for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA965267 | KMT2D Antibody | Human | ELISA,IHC |
KMT2D Proteins
KMT2D Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP014628HU CSB-EP014628HU CSB-BP014628HU CSB-MP014628HU CSB-EP014628HU-B |
Recombinant Human Histone-lysine N-methyltransferase 2D (KMT2D), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KMT2D Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP744111MO CSB-EP744111MO CSB-BP744111MO CSB-MP744111MO CSB-EP744111MO-B |
Recombinant Mouse Histone-lysine N-methyltransferase MLL2 (Mll2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
