ITPRIPL1
ITPRIPL1，全称为Inositol 1,4,5-Triphosphate Receptor Interacting Protein-Like 1，常见别名包括ITPRIP like 1、inositol 1,4,5-trisphosphate receptor interacting protein-like 1等。该蛋白参与调节内质网中的钙释放，其表达与多种疾病相关，如脊髓小脑共济失调15型等。研究表明，ITPRIPL1作为CD3ε的抑制配体，能够抑制T细胞的活化，从而促进肿瘤的免疫逃逸。这一发现为肿瘤免疫治疗提供了新的靶点，相关抗体已进入临床研究阶段。此外，ITPRIPL1的表达也可能与睾丸免疫豁免有关，其在睾丸中的高表达有助于维持免疫系统的平衡。目前，针对ITPRIPL1的药物研发正在积极进行中，有望为肿瘤治疗和免疫调节领域带来新的突破。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITPRIPL1 at 2 μg/ml can bind Anti-ITPRIPL1 recombinant antibody (CSB-RA756966MA1HU). The EC50 is 6.537-7.663 ng/mL.
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITPRIPL1 at 2 μg/ml can bind Anti-ITPRIPL1 recombinant antibody (CSB-RA756966MA1HU). The EC50 is 3.759-4.428 ng/mL.
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Itpripl1 at 2 μg/ml can bind Anti-ITPRIPL1 recombinant antibody (CSB-RA756966MA1HU). The EC50 is 0.7534-0.9877 ng/mL.
ITPRIPL1 Recombinant Monoclonal Antibody (CSB-RA756966MA1HU)
验证数据
The Binding Activity of Macaca fascicularis ITPRIPL1 with Anti-ITPRIPL1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITPRIPL1 (CSB-MP6125MOV) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 3.759-4.428 ng/mL.
The Binding Activity of Human ITPRIPL1 with Anti-ITPRIPL1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ITPRIPL1 (CSB-MP756966HU) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 6.537-7.663 ng/mL.
The Binding Activity of Mouse Itpripl1 with Anti-ITPRIPL1 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Itpripl1 (CSB-MP011916MO1) at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody. The EC50 is 0.7534-0.9877 ng/mL.
ITPRIPL1 Antibodies
ITPRIPL1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-RA756966MA1HU | ITPRIPL1 Recombinant Monoclonal Antibody | Human, Macaca fascicularis | ELISA |
ITPRIPL1 Proteins
ITPRIPL1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP756966HU CSB-EP756966HU CSB-BP756966HU CSB-EP756966HU-B |
Recombinant Human Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP756966HU | Recombinant Human Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1), partial (Active) | Mammalian cell |
