ITGA4

ITGA4全称为整合素α4，是细胞表面重要的黏附分子，常与β1或β7亚基结合形成复合蛋白，也称作CD49d或VLA-4。这类蛋白广泛分布于免疫细胞表面，通过调控细胞迁移参与炎症反应和免疫应答，ITGA4功能异常与多发性硬化、溃疡性结肠炎等自身免疫疾病密切相关，在肿瘤转移过程中也表现出促进癌细胞扩散的特性。目前针对该蛋白的药物开发已取得突破，例如那他珠单抗通过阻断其活性，显著降低多发性硬化患者的复发率，但需警惕进行性多脑白质病等罕见副作用。近年研究还发现，小分子抑制剂在类风湿关节炎模型中能有效缓解关节损伤，部分候选药物已进入II期临床试验。随着对蛋白构象变化机制的深入解析，新一代高选择性调节剂的开发为精准治疗提供了新方向。

热销产品

Recombinant Human Integrin alpha-4 (ITGA4), partial (CSB-EP011867HU1)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ITGA4 Recombinant Monoclonal Antibody (CSB-RA225859A0HU)

验证数据

Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: ITGA4 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 115, 26 kDa
Observed band size: 140 kDa

ITGA4 Antibody

ITGA4 Protein

ITGA4 ELISA Kit

ITGA4 Antibodies

ITGA4 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA011867GA01HU	ITGA4 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA977888	ITGA4 Antibody	Human	ELISA,WB
CSB-PA005224	ITGA4 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA011259	Phospho-ITGA4 (S1027) Antibody	Human,Mouse	IHC, IF, ELISA
CSB-PA011260	ITGA4 Antibody	Human,Mouse	WB, ELISA
CSB-PA011867LA01HU	ITGA4 Antibody	Human	ELISA, IHC, IF
CSB-PA011867LB01HU	ITGA4 Antibody, HRP conjugated	Human	ELISA
CSB-PA011867LC01HU	ITGA4 Antibody, FITC conjugated	Human
CSB-PA011867LD01HU	ITGA4 Antibody, Biotin conjugated	Human	ELISA
CSB-RA225859A0HU	ITGA4 Recombinant Monoclonal Antibody	Human	ELISA, WB

ITGA4 Proteins

ITGA4 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP011867HU CSB-EP011867HU CSB-BP011867HU CSB-MP011867HU CSB-EP011867HU-B	Recombinant Human Integrin alpha-4 (ITGA4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011867HU1	Recombinant Human Integrin alpha-4 (ITGA4), partial	E.coli

ITGA4 Proteins for Xenopus laevis (African clawed frog)

产品货号	产品名称	来源
CSB-YP838629XBE CSB-EP838629XBE CSB-BP838629XBE CSB-MP838629XBE CSB-EP838629XBE-B	Recombinant Xenopus laevis Integrin alpha-4 (itga4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli