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IDH1

IDH1,即异柠檬酸脱氢酶1,别名IDH1突变体、IDH1p. Arg132His等特定突变体的名称。它是一种在细胞质和过氧化物酶体中发挥作用的酶,由人体细胞自身的基因编码。IDH1的主要作用机制是催化异柠檬酸转化为α-酮戊二酸(α-KG)的氧化脱羧反应,同时将NADP+还原为NADPH。这一过程为细胞提供了重要的抗氧化分子,并且α-KG作为一种辅酶,参与调节多种依赖α-KG的双加氧酶的活性,影响细胞的表观遗传修饰和代谢过程。IDH1在生物学上的意义非常广泛,它不仅参与细胞的能量代谢和维持氧化还原平衡,还与多种疾病的发生发展密切相关。IDH1的突变形式在某些癌症如胶质瘤、急性髓系白血病(AML)和肝内胆管癌中较为常见,这些突变通常导致代谢产物2-羟基戊二酸(2-HG)的积累,进而影响细胞的甲基化状态和基因表达调控。此外,IDH1还参与调节PI3K/AKT/mTOR等信号通路,这些通路与细胞的增殖、凋亡、血管生成和代谢等生理过程紧密相关。因此,IDH1不仅在维持细胞正常生理功能中发挥关键作用,也是癌症治疗中的潜在靶点。

热销产品

Recombinant Human Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (CSB-EP010989HU(A4))

验证数据

CSB-EP010989HU(A4)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IDH1 Antibody (CSB-PA010989ESR1HU)

验证数据

CSB-PA010989ESR1HU

Western blot
All lanes: IDH1 antibody at 3µg/ml
Lane 1: Mouse liver tissue
Lane 2: Hela whole cell lysate
Lane 3: NIH/3T3 whloe cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa

CSB-PA010989ESR1HU

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA010989ESR1HU at dilution of 1:100

CSB-PA010989ESR1HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010989ESR1HU at dilution of 1:100

IDH1 Antibodies

IDH1 for Mus musculus (Mouse)

IDH1 for Homo sapiens (Human)

IDH1 Proteins

IDH1 Proteins for Sus scrofa (Pig)

IDH1 Proteins for Rattus norvegicus (Rat)

IDH1 Proteins for Mus musculus (Mouse)

IDH1 Proteins for Homo sapiens (Human)

IDH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

IDH1 Proteins for Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)

IDH1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

IDH1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

IDH1 Proteins for Pongo abelii (Sumatran orangutan)

IDH1 Proteins for Ovis aries (Sheep)

IDH1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

IDH1 Proteins for Bos taurus (Bovine)