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GLP1R

GLP-1R,即胰高血糖素样肽-1受体,别名GLP-1 recepto、GLP-1-R、GLP-1R,它属于B1类G蛋白偶联受体(GPCR),是调节体内血糖水平的重要受体,被广泛认为是2型糖尿病和肥胖症的治疗靶点。GLP-1R激动剂通过模拟天然GLP-1的作用,以葡萄糖浓度依赖的方式增强胰岛素分泌、抑制胰高血糖素分泌,并能够延缓胃排空,减少食物摄入,降低血糖。GLP-1R的信号传导主要通过与多种G蛋白(如Gαs、Gαi、Gαo和Gαq/11)偶联来实现,激活不同的细胞内信号通路,如cAMP/PKA途径,进而提高葡萄糖感受性,刺激胰岛素的分泌。GLP-1R的生物学意义主要体现在其对维持血糖稳态的贡献上。它不仅在降低血糖方面发挥作用,还具有减重、降压和改善血脂谱等多重效应。此外,GLP-1R激动剂的研究和开发已成为糖尿病和肥胖治疗领域的热点,全球市场规模巨大且持续增长。随着对GLP-1R结构和功能认识的深入,新型激动剂的设计与开发不断取得进展,为治疗相关代谢性疾病提供了新的思路和希望。

热销产品

Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)

验证数据

CSB-MP009514HUb1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP009514HUb1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.

GLP1R monoclonal antibody (CSB-RA009514MA1HU)

验证数据

CSB-RA009514MA1HU

The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC50 is 54.54-94.23 ng/mL.

CSB-RA009514MA1HU

Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

GLP1R Antibodies

GLP1R for Homo sapiens (Human)

GLP1R for Mus musculus (Mouse)

GLP1R Proteins

GLP1R Proteins for Rattus norvegicus (Rat)

GLP1R Proteins for Mus musculus (Mouse)

GLP1R Proteins for Homo sapiens (Human)

GLP1R Proteins for Homo sapiens(Human)

GLP1R ELISA Kit

GLP1R ELISA Kit for Mus musculus (Mouse)