GLP1R
GLP-1R,即胰高血糖素样肽-1受体,别名GLP-1 recepto、GLP-1-R、GLP-1R,它属于B1类G蛋白偶联受体(GPCR),是调节体内血糖水平的重要受体,被广泛认为是2型糖尿病和肥胖症的治疗靶点。GLP-1R激动剂通过模拟天然GLP-1的作用,以葡萄糖浓度依赖的方式增强胰岛素分泌、抑制胰高血糖素分泌,并能够延缓胃排空,减少食物摄入,降低血糖。GLP-1R的信号传导主要通过与多种G蛋白(如Gαs、Gαi、Gαo和Gαq/11)偶联来实现,激活不同的细胞内信号通路,如cAMP/PKA途径,进而提高葡萄糖感受性,刺激胰岛素的分泌。GLP-1R的生物学意义主要体现在其对维持血糖稳态的贡献上。它不仅在降低血糖方面发挥作用,还具有减重、降压和改善血脂谱等多重效应。此外,GLP-1R激动剂的研究和开发已成为糖尿病和肥胖治疗领域的热点,全球市场规模巨大且持续增长。随着对GLP-1R结构和功能认识的深入,新型激动剂的设计与开发不断取得进展,为治疗相关代谢性疾病提供了新的思路和希望。
热销产品
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
GLP1R monoclonal antibody (CSB-RA009514MA1HU)
验证数据
The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC50 is 54.54-94.23 ng/mL.
Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
GLP1R Antibodies
GLP1R for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA009514LD01HU | GLP1R Antibody, Biotin conjugated | Human | ELISA |
CSB-PA009514YA01HU | GLP1R Antibody | Human, Mouse | ELISA, WB, IF |
CSB-PA009514YB01HU | GLP1R Antibody, HRP conjugated | Human | ELISA |
CSB-PA009514YD01HU | GLP1R Antibody, Biotin conjugated | Human | ELISA |
CSB-PA009514LA01HU | GLP1R Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA002699 | GLP1R Antibody | Human,Mouse | WB, IF, ELISA |
CSB-PA183226 | GLP1R Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA009514MA1HU | GLP1R monoclonal antibody | Human | ELISA, FC |
GLP1R for Mus musculus (Mouse)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA009514HA01MO | Glp1r Antibody | Mouse | ELISA, WB |
CSB-PA009514HB01MO | Glp1r Antibody, HRP conjugated | Mouse | ELISA |
CSB-PA009514HC01MO | Glp1r Antibody, FITC conjugated | Mouse | |
CSB-PA009514HD01MO | Glp1r Antibody, Biotin conjugated | Mouse | ELISA |
GLP1R Proteins
GLP1R Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast |
CSB-CF009514RA | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r) | in vitro E.coli expression system |
CSB-EP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | E.coli |
CSB-BP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Baculovirus |
CSB-YP009514RA | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast |
GLP1R Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009514MO1 CSB-BP009514MO1 CSB-MP009514MO1 CSB-EP009514MO1-B |
Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF009514MO | Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r) | in vitro E.coli expression system |
CSB-EP009514MO1 | Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial | E.coli |
GLP1R Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-EP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | E.coli |
CSB-YP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | Yeast |
CSB-MP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | Mammalian cell |
CSB-CF009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R) | in vitro E.coli expression system |
CSB-CF009514HU(A4) | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R) | in vitro E.coli expression system |
CSB-MP009514HU(A4) | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R)-VLPs | Mammalian cell |
CSB-MP009514HUb1 | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) | Mammalian cell |
CSB-EP009514HUd7 | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | E.coli |
GLP1R Proteins for Homo sapiens(Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-BP009514HU | Recombinant human Glucagon-like peptide 1 receptor | Baculovirus |
GLP1R ELISA Kit
GLP1R ELISA Kit for Mus musculus (Mouse)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL009514MO | Mouse Glucagon-like peptide 1 receptor(GLP1R) ELISA kit | serum, plasma, tissue homogenates | 0.11 ng/ml |