GCGR
胰高血糖素受体(Gprotein-coupledreceptor, GCGR)属于B类G蛋白偶联受体家族(GPCRs),在维持人体血糖稳态中发挥关键作用。其它相关的G-蛋白偶联受体还包括胰高血糖素-样肽-1受体(GLP-I)、胰高血糖素-样肽-2受体(GLP-2)和胃抑制性多肽受体等。GCGR主要在肝脏和肾脏中表达,在心脏,脂肪组织,脾脏,胸腺,肾上腺,胰腺,大脑皮层和胃肠道中有少量发现。GCGR的天然配体为胰高血糖素(Glucagon),在体内,GCGR与其配体结合,主要通过激活Gs蛋白行使其功能。激活的GCGR通过与异源三聚体Gs结合,诱导腺苷酸环化酶活化,从而产生cAMP,激活蛋白激酶A,使肝糖原分解和糖异生增加,导致体内血糖升高。研究表明,针对GCGR靶点的特异性抗体可促进1型糖尿病动物的β细胞再生,改善1型糖尿病患者治疗。陆续有研究报道,GCGR还与肾脏、脂肪肝、肥胖等代谢疾病相关。目前,GCGR已成为抵抗糖尿病的重要靶点。
Recombinant Human GCGR 活性蛋白实验验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized human GCGR at 2 μg/ml can bind Anti-GCGR recombinant antibody (CSB-RA009316A1HU), the EC50 is 3.747-6.666 ng/mL.
GCGR Antibodies
GCGR for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA002705 | GCGR Antibody | Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA222690 | GCGR Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA569512 | GCGR Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA009316LA01HU | GCGR Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA009316LB01HU | GCGR Antibody, HRP conjugated | Human | ELISA |
CSB-PA009316LC01HU | GCGR Antibody, FITC conjugated | Human | |
CSB-PA009316LD01HU | GCGR Antibody, Biotin conjugated | Human | ELISA |
CSB-RA009316A1HU | GCGR Recombinant Monoclonal Antibody | Human | ELISA |
GCGR Proteins
GCGR Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009316RA1 CSB-EP009316RA1 CSB-BP009316RA1 CSB-MP009316RA1 CSB-EP009316RA1-B |
Recombinant Rat Glucagon receptor (Gcgr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF009316RA | Recombinant Rat Glucagon receptor (Gcgr) | in vitro E.coli expression system |
GCGR Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009316HU1 | Recombinant Human Glucagon receptor (GCGR), partial | Yeast |
CSB-CF009316HU | Recombinant Human Glucagon receptor (GCGR) | in vitro E.coli expression system |
CSB-EP009316HU1 | Recombinant Human Glucagon receptor (GCGR), partial | E.coli |
CSB-BP009316HU1 | Recombinant Human Glucagon receptor (GCGR), partial,Baculovirus | Baculovirus |
CSB-MP009316HU1 | Recombinant Human Glucagon receptor (GCGR), partial (Active) | Mammalian cell |
CSB-BP009316HU | Recombinant Human Glucagon receptor (GCGR), partial | Baculovirus |
CSB-MP009316HU | Recombinant Human Glucagon receptor (GCGR)-VLPs | Mammalian cell |
GCGR Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP009316MO | Recombinant Mouse Glucagon receptor (Gcgr), partial | Yeast |
CSB-EP009316MO | Recombinant Mouse Glucagon receptor (Gcgr), partial | E.coli |
CSB-BP009316MO CSB-MP009316MO CSB-EP009316MO-B |
Recombinant Mouse Glucagon receptor (Gcgr), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |