FGFR4
FGFR4，即成纤维细胞生长因子受体4，别名JTK2、TKF、Fibroblast growth factor receptor 4，是一种重要的酪氨酸激酶受体。FGFR4由FGFR4基因编码，广泛分布于骨骼、肾脏和肝脏等组织中。其作用机制主要是通过与成纤维细胞生长因子结合，激活下游的RAS/RAF/MEK/ERK和PI3K/AKT等信号通路，从而调控细胞的增殖、分化、迁移和存活。FGFR4在骨骼发育、肾脏功能维持等生物学过程中发挥着关键作用。异常的FGFR4活性与多种疾病如骨骼畸形、癌症和肾脏疾病等有关，使其成为药物开发的重要靶点。
热销产品
FGFR4 Recombinant Monoclonal Antibody (CSB-RA927449A0HU)
验证数据
IHC image of CSB-RA927449A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
FGFR4 Antibodies
FGFR4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA008648GA01HU | FGFR4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA556085 | FGFR4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA977910 | Phospho-FGFR4 (Tyr642) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008250 | Phospho-FGFR4 (Y642) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA604644 | FGFR4 Antibody | Human | WB, ELISA |
| CSB-PA008648LA01HU | FGFR4 Antibody | Human | ELISA, IHC, IF |
| CSB-PA008648LB01HU | FGFR4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008648LC01HU | FGFR4 Antibody, FITC conjugated | Human | |
| CSB-PA008648LD01HU | FGFR4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA927449A0HU | FGFR4 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
FGFR4 Proteins
FGFR4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008648HU1 CSB-EP008648HU1 CSB-BP008648HU1 CSB-MP008648HU1 CSB-EP008648HU1-B |
Recombinant Human Fibroblast growth factor receptor 4 (FGFR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008648HU | Recombinant Human Fibroblast growth factor receptor 4 (FGFR4) | in vitro E.coli expression system |
FGFR4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008648DIL CSB-EP008648DIL CSB-BP008648DIL CSB-MP008648DIL CSB-EP008648DIL-B |
Recombinant Danio rerio Fibroblast growth factor receptor 4 (fgfr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR4 Proteins for Coturnix coturnix (Common quail) (Tetrao coturnix)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008648CRA CSB-EP008648CRA CSB-BP008648CRA CSB-MP008648CRA CSB-EP008648CRA-B |
Recombinant Coturnix coturnix Fibroblast growth factor receptor 4 (FGFR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR4 Proteins for Pleurodeles waltl (Iberian ribbed newt)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008648EWZ CSB-EP008648EWZ CSB-BP008648EWZ CSB-MP008648EWZ CSB-EP008648EWZ-B |
Recombinant Pleurodeles waltl Fibroblast growth factor receptor 4 (FGFR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR4 Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008648XBE CSB-EP008648XBE CSB-BP008648XBE CSB-MP008648XBE CSB-EP008648XBE-B |
Recombinant Xenopus laevis Fibroblast growth factor receptor 4 (fgfr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR4 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008648RA CSB-EP008648RA CSB-BP008648RA CSB-MP008648RA CSB-EP008648RA-B |
Recombinant Rat Fibroblast growth factor receptor 4 (Fgfr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
