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EGFR(Epidermal Growth Factor Receptor)是一个经典的跨膜蛋白,属于酪氨酸激酶型受体。EGFR广泛分布于哺乳动物上皮细胞、成纤维细胞、胶质细胞、角质细胞等细胞表面,EGFR信号通路对细胞的生长、增殖和分化等生理过程发挥重要的作用。EGFR通过与配体结合而激活,介导上皮生长因子(EGF)细胞增殖和信号传导。EGFR被配体激活后启动胞内信号传导,经过细胞质中衔接蛋白、酶的级联反应,转录因子激活基因的转录,介导细胞迁移和黏附等过程,且与肿瘤的形成和恶化密切相关。许多研究表明EGFR在非小细胞肺癌、头颈部肿瘤、乳腺癌、膀胱癌、结直肠癌、卵巢癌等多种肿瘤中存在突变或高表达。因此,已经有很多研究把EGFR作为肿瘤的治疗靶点。近年来,靶向EGFR药物已成为抗肿瘤药物研究的热点。


Recombinant Human Epidermal growth factor receptor(EGFR),partial (Active) CSB-MP007479HU


High Purity Validated by

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Cetuximab, the EC50 of human EGFR protein is 0.6919-1.047 ng/ml.

Excellent Bioactivity Validated by LSPR Assay

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU



IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.


Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA159341MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

EGFR Antibodies

EGFR for Homo sapiens (Human)

EGFR for H

EGFR Proteins

EGFR Proteins for Gallus gallus (Chicken)

EGFR Proteins for Apis mellifera (Honeybee)

EGFR Proteins for Macaca mulatta (Rhesus macaque)

EGFR Proteins for Drosophila melanogaster (Fruit fly)

EGFR Proteins for Homo sapiens (Human)


EGFR ELISA Kit for Homo sapiens (Human)