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CTLA4

CTLA4,即细胞毒性T淋巴细胞相关蛋白4,别名CD152。CTLA4是一种主要由活化的T细胞表达的跨膜蛋白,由CTLA4基因编码。它的作用机制是通过与B7家族分子(如CD80和CD86)结合,抑制T细胞的激活和增殖,从而调节免疫反应。CTLA4的活性在自身免疫性疾病和抗肿瘤免疫中具有重要作用,其表达水平的变化可能影响免疫耐受和免疫病理过程。CTLA4的功能异常与某些自身免疫性疾病如系统性红斑狼疮、类风湿关节炎等有关,同时,CTLA4也是免疫检查点抑制剂治疗的靶点之一,相关药物如伊普利姆玛(Ipilimumab)已用于治疗黑色素瘤等癌症。

热销产品

Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) (CSB-MP006163HU1)

验证数据

CSB-MP006163HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP006163HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody(CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP006163HU1

The purity of CTLA4 was greater than 90% as determined by SEC-HPLC.

CTLA4 Recombinant Monoclonal Antibody (CSB-RA213310A0HU)

验证数据

CSB-RA213310A0HU

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA213310A0HU

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CTLA4 Antibodies

CTLA4 for Homo sapiens (Human)

CTLA4 Proteins

CTLA4 Proteins for Homo sapiens (Human)

CTLA4 Proteins for Oryctolagus cuniculus (Rabbit)

CTLA4 Proteins for Mus musculus (Mouse)

CTLA4 Proteins for Sus scrofa (Pig)

CTLA4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CTLA4 ELISA Kit

CTLA4 ELISA Kit for Homo sapiens (Human)

CTLA4 ELISA Kit for Mus musculus (Mouse)