CSF1R
Csf1r，全称是集落刺激因子1受体（Colony-Stimulating Factor 1 Receptor），常见别名包括M-CSFR、CSF-1R、CD115和FMS。该蛋白主要存在于单核吞噬细胞，特别是巨噬细胞和单核细胞中，参与多种生物过程。Csf1r蛋白能够响应IL34和CSF1的诱导，促进促炎趋化因子的释放，对先天免疫和炎症起到重要作用。此外，Csf1r蛋白还在调节破骨细胞的增殖和分化、骨吸收、正常骨骼和牙齿发育方面发挥着关键作用，并且对男性和女性的正常生育能力以及怀孕期间乳腺中乳管和腺泡结构的发育至关重要。
近年来，Csf1r蛋白已成为药物研发的重要靶点。由于高水平的CSF1和Csf1r蛋白在多种癌症中被报道，且与不良预后相关，因此针对Csf1r蛋白的小分子抑制剂和抗体正在临床开发中，显示出抗肿瘤活性。例如，Incyte和Syndax Pharmaceuticals公司开发的Axatilimab，以及罗氏制药和Celleron Therapeutics共同开发的Emactuzumab，都是针对Csf1r蛋白的抑制剂，分别用于治疗慢性移植物抗宿主病和腱鞘巨细胞瘤等疾病。这些药物在临床试验中展现出良好的疗效，为Csf1r蛋白靶点药物的研发提供了新的希望。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse Csf1(CSB-MP006043MO) at 2 μg/ml can bind Mouse Csf1r. The EC50 is 3.226-4.264 ng/mL.
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
①Measured by its binding ability in a functional ELISA. Immobilized Human CSF1R at 2 μg/ml can bind Anti-CSF1R recombinant antibody (CSB-RA006044MA1HU). The EC50 is 1.800-2.218 ng/mL.
Activity
②Measured by its binding ability in a functional ELISA. Immobilized Human CSF1R at 2 μg/ml can bind Human CSF1 (CSB-MP006043HU1). The EC50 is 22.53-25.44 ng/mL.
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
验证数据
Western Blot analysis of COLO cells using c-Fms Polyclonal Antibody
Western Blot analysis of HEPG2 using c-Fms Polyclonal Antibody
Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit (CSB-E10012h)
验证数据
货号：CSB-E10012h
规格：96T/48T
灵敏度：0.039 ng/mL
检测范围：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CSF1R Antibodies
CSF1R for Felis silvestris catus
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006044LA01CA | CSF1R Antibody | Felis silvestris catus | ELISA |
CSF1R for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA084386 | Phospho-CSF1R (Tyr809) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA924224 | Phospho-CSF1R (Tyr561) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA202220 | Phospho-CSF1R (Tyr708) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA696464 | CSF1R (Ab-809) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA152912 | Phospho-CSF1R (Tyr699) Antibody | Human | ELISA,WB |
| CSB-PA940519 | Phospho-CSF1R (Tyr809) Antibody | Human | ELISA,IHC |
| CSB-PA001596 | CSF1R Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA001597 | CSF1R Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA007328 | Phospho-CSF1R (Y809) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007329 | Phospho-CSF1R (Y699) Antibody | Human | WB, ELISA |
| CSB-PA007330 | Phospho-CSF1R (Y708) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007331 | Phospho-CSF1R (Y723) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007332 | Phospho-CSF1R (Y561) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007333 | Phospho-CSF1R (Y809) Antibody | Human | IHC, ELISA |
| CSB-PA007334 | CSF1R Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007335 | CSF1R Antibody | Human | WB, ELISA |
| CSB-PA007337 | CSF1R Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA300271 | CSF1R Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA678661 | CSF1R Antibody | Human,Mouse,Rat | ELISA,WB |
CSF1R Proteins
CSF1R Proteins for Felis catus (Cat) (Felis silvestris catus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006044CA CSB-BP006044CA CSB-MP006044CA CSB-EP006044CA-B |
Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006044CA | Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | E.coli |
CSF1R Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006044HU CSB-EP006044HU CSB-BP006044HU CSB-EP006044HU-B |
Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP006044HU | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Mammalian cell |
| CSB-MP006044HUi10 | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Mammalian cell |
| CSB-MP006044HUd7 | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial (Active) | Mammalian cell |
CSF1R Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006044MO CSB-EP006044MO CSB-BP006044MO CSB-EP006044MO-B |
Recombinant Mouse Macrophage colony-stimulating factor 1 receptor (Csf1r), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSF1R Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP888246DIL CSB-EP888246DIL CSB-BP888246DIL CSB-MP888246DIL CSB-EP888246DIL-B |
Recombinant Danio rerio Macrophage colony-stimulating factor 1 receptor (csf1r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1R ELISA Kit
CSF1R ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E10012h | Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
CSF1R ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL006044RA | Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
