CRTAM
CRTAM(CD355)是免疫球蛋白超家族(Ig-SF)的新成员,同时也是nectin样蛋白超家族的成员。它作为细胞表面跨膜蛋白,在免疫系统的形成、应答和细胞交互中扮演重要角色。CRTAM在活化的人NK细胞、CD8+ T细胞和CD4+ T细胞子集上表达,参与细胞粘附、极性和增殖,并调节淋巴细胞功能,如促进TCD8+细胞在淋巴结内的粘附和保留。 CRTAM与多种疾病关联,包括炎症、哮喘、恶性间皮瘤和某些肿瘤疾病。CRTAM能够影响CD4+ T细胞的极化,促进CD4+ T细胞的进一步分化,并增强细胞因子的分泌能力。此外,CRTAM在免疫过程中对NK细胞杀伤肿瘤细胞起到关键作用,呈现出潜在的肿瘤靶向策略。CRTAM还可以与Necl-2相互作用,在体外促进NK细胞的细胞毒性和CD8+ T细胞的IFN-γ分泌,以及在体内NK细胞介导的对表达Necl-2的肿瘤的排斥反应。 CRTAM的表达受到严格的调控,主要表达于激活的免疫细胞上。在健康人的外周血单个核细胞(PBMC)中,CRTAM的表达量很低,但在哮喘病人的PBMC中高表达。CRTAM的启动子与IL-2一样,受到AP-1转录因子的调控。CRTAM激活后会刺激CD8+ T细胞分泌IFN-γ,并增强CD8+ T细胞和NK细胞的杀伤能力。
热销产品
● Recombinant Mouse Cytotoxic and regulatory T-cell molecule (Crtam), partial (Active)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Cadm1(CSB-MP004425MO) at 2μg/mL can bind Mouse Crtam,the EC50 is 54.36 -61.77 ng/mL.
● Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CRTAM at 2μg/mL can bind Human CADM1(CSB-MP004425HUd9),the EC50 is 2.277-2.649 ng/mL.
CRTAM Antibodies
CRTAM for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA243691 | CRTAM Antibody | Human | ELISA,IHC |
CSB-PA725805 | CRTAM Antibody | Human | ELISA,IHC |
CRTAM Proteins
CRTAM Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP005998HU1 CSB-EP005998HU1 CSB-BP005998HU1 CSB-EP005998HU1-B |
Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF005998HU | Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM) | in vitro E.coli expression system |
CSB-AP005441HU | Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active) | Mammalian cell |
CSB-MP005998HU1d7 | Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM), partial (Active) | Mammalian cell |
CRTAM Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP614820MO CSB-EP614820MO CSB-BP614820MO CSB-EP614820MO-B |
Recombinant Mouse Cytotoxic and regulatory T-cell molecule (Crtam), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CRTAM ELISA Kit
CRTAM ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL005998HU | Human Cytotoxic and regulatory T-cell molecule(CRTAM) ELISA kit | Request Information |