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CLDN18

CLDN18,即紧密连接蛋白18,别名Claudin-18。CLDN18由人类CLDN18基因编码,该基因位于3号染色体的3q28区域。CLDN18是一种紧密连接蛋白,主要参与形成细胞间的紧密连接,调节细胞旁路的通透性和维持上皮细胞层的完整性。其作用机制涉及与细胞膜上的其他紧密连接蛋白相互作用,形成稳定的紧密连接结构,控制分子和离子在细胞间的流动。CLDN18在肺泡上皮细胞和胃上皮细胞中高度表达,对于肺和胃的发育和功能至关重要。CLDN18的异常表达与多种疾病相关,包括肺癌和胃癌。特别是在肺癌中,CLDN18的表达与肿瘤的侵袭性和预后不良相关,是潜在的诊断标志物和治疗靶点。

热销产品

Recombinant Macaca fascicularis Claudin 18.2 (CLDN18.2)-VLPs (Active) (CSB-MP4304MOV)

验证数据

CSB-MP4304MOV

CSB-MP4304MOV is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP4304MOV

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CLDN18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant Antibody (CSB-RA005498A1HU), the EC50 is 2.806-3.641 ng/ml.

CSB-MP4304MOV

The purity of VLPs was greater than 90% as determined by SEC-HPLC

Recombinant Mouse Claudin-18.2 (Cldn18.2)-VLPs (Active) (CSB-MP005498MO(F3))

验证数据

CSB-MP005498MO(F3)

CSB-MP005498MO(F3) is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP005498MO(F3)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Cldn18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005498A1HU), the EC50 is 6.115-11.01 ng/mL.

Recombinant Human Claudin-18.2 (CLDN18.2)-VLPs (Active) (CSB-MP005498HU(A5))

验证数据

CSB-MP005498HU(A5)

Western Blot
CSB-MP005498HU(A5) is detected by Mouse anti-6*His monoclonal antibody.The three bands respectively correspond to monomer, Homodimer, Homotrimer

CSB-MP005498HU(A5)

Activity
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.

CSB-MP005498HU(A5)

The presence of VLP-like structures was confirmed by TEM

CSB-MP005498HU(A5)

Western Blot
CSB-MP005498HU(A5) is detected by Anti-Claudin 18 Antibody.The two bands respectively correspond to monomer, Homodimer

CLDN18 Recombinant Monoclonal Antibody (CSB-RA005498A2HU)

验证数据

CSB-RA005498A2HU

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA005498A2HU

The Binding Activity of Human CLDN18.2 with Anti-CLDN18 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/mL can bind Anti-CLDN18 recombinant antibody, the EC50 is 2.947-8.782 ng/mL.

CLDN18 Antibodies

CLDN18 for Homo sapiens (Human)

CLDN18 Proteins

CLDN18 Proteins for Mus musculus (Mouse)

CLDN18 Proteins for Homo sapiens (Human)

CLDN18 Proteins for Bos taurus (Bovine)