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Cytokine-inducible SH2-containing protein is a protein in humans that is encoded by CISH gene. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

CISH Antibodies

CISH for Homo sapiens (Human)

CISH Proteins

CISH Proteins for Rattus norvegicus (Rat)

CISH Proteins for Bos taurus (Bovine)

CISH Proteins for Mus musculus (Mouse)

CISH Proteins for Gallus gallus (Chicken)

CISH Proteins for Homo sapiens (Human)