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Cyclin-dependent kinase inhibitor 1 is a protein in humans that is encoded by CDKN1A gene. May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.

CDKN1A Antibodies

CDKN1A for Homo sapiens (Human)

CDKN1A Proteins

CDKN1A Proteins for Homo sapiens (Human)

CDKN1A Proteins for Mus musculus (Mouse)

CDKN1A Proteins for Felis catus (Cat) (Felis silvestris catus)