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G1/S-specific cyclin-D2is a protein in humans that is encoded by CCND2 gene. Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.

CCND2 Antibodies

CCND2 for Homo sapiens (Human)

CCND2 Proteins

CCND2 Proteins for Rattus norvegicus (Rat)

CCND2 Proteins for Mus musculus (Mouse)

CCND2 Proteins for Homo sapiens (Human)

CCND2 Proteins for Gallus gallus (Chicken)

CCND2 Proteins for Xenopus laevis (African clawed frog)

CCND2 Proteins for Bos taurus (Bovine)

CCND2 Proteins for Sus scrofa (Pig)