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G1/S-specific cyclin-D1 is a protein in humans that is encoded by CCND1 gene. Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.

CCND1 Antibodies

CCND1 for Homo sapiens (Human)

CCND1 Proteins

CCND1 Proteins for Homo sapiens (Human)

CCND1 Proteins for Mus musculus (Mouse)

CCND1 Proteins for Rattus norvegicus (Rat)

CCND1 Proteins for Gallus gallus (Chicken)

CCND1 Proteins for Xenopus laevis (African clawed frog)

CCND1 Proteins for Bos taurus (Bovine)

CCND1 Proteins for Pongo abelii (Sumatran orangutan)

CCND1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CCND1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)