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BRAF

BRAF,即B型快速反应蛋白激酶,它是一种丝氨酸/苏氨酸激酶,属于RAF家族成员。BRAF由BRAF基因编码,广泛存在于多种组织中,尤其是在神经细胞和皮肤细胞中。其作用机制涉及与RAS蛋白的激活形式结合后,发生磷酸化和二聚化,进而激活下游的MEK/ERK信号通路,该通路在细胞增殖、分化、迁移和凋亡等过程中发挥关键作用。BRAF的生物学意义在于其在调控细胞周期、细胞应激反应以及细胞内信号传递中的核心作用。BRAF基因的突变,特别是在其激酶结构域中,与多种癌症的发生发展有关,如黑色素瘤、结直肠癌等,因此BRAF也是癌症治疗中的一个重要靶点。

热销产品

BRAF Recombinant Monoclonal Antibody (CSB-RA171021A0HU)

验证数据

CSB-RA171021A0HU

IHC image of CSB-RA171021A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA171021A0HU

IHC image of CSB-RA171021A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Serine/threonine-protein kinase B-raf(BRAF) ELISA kit (CSB-EL002791HU)

验证数据

CSB-EL002791HU 标准曲线

货号:CSB-EL002791HU

规格:96T/48T

灵敏度:7.8 pg/mL

检测范围:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

BRAF Antibodies

BRAF for Homo sapiens (Human)

BRAF Proteins

BRAF Proteins for Gallus gallus (Chicken)

BRAF Proteins for Homo sapiens (Human)

BRAF Proteins for Mus musculus (Mouse)

BRAF Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

BRAF Proteins for Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

BRAF ELISA Kit

BRAF ELISA Kit for Homo sapiens (Human)