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BCL2

BCL2,即B细胞淋巴瘤/白血病-2基因,别名包括Bcl-2家族中的抗凋亡蛋白,如Bcl-2、Bcl-XL、Bcl-W、Mcl-1等。它最初在血液淋巴细胞中被发现,能够显著抑制细胞死亡。BCL2基因的作用机制复杂,主要通过调控线粒体途径来抑制细胞凋亡,它能够阻止细胞色素c的释放,抑制活化的Caspases对线粒体的影响,从而维持细胞生存。此外,BCL2还能通过抗氧化作用、抑制钙离子跨膜流动和调节离子通道蛋白功能等多种机制来发挥作用。BCL2在细胞凋亡的信号通路中扮演着关键角色,它通过与Bax等促凋亡蛋白相互作用,形成二聚体,调节线粒体膜的通透性,进而影响细胞色素c的释放和Caspase级联反应的激活。BCL2的生物学意义重大,它不仅在细胞存活和凋亡的平衡中发挥作用,还与多种疾病的发生发展密切相关,包括癌症、神经退行性疾病等。BCL2的功能失调可能导致细胞凋亡途径的异常激活,影响细胞的正常生理功能。

热销产品

Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2) (CSB-CF002611RA)

验证数据

CSB-CF002611RA

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BCL2 Recombinant Monoclonal Antibody (CSB-RA564360A0HU)

验证数据

CSB-RA564360A0HU

Western Blot
Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, U-937 whole cell lysate, THP-1 whole cell lysate, Raji whole cell lysate, Mouse Spleen whole cell lysate
All lanes: Bcl-2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 27, 23 kDa
Observed band size: 27 kDa

CSB-RA564360A0HU

IHC image of CSB-RA564360A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Rat B-cell CLL/lymphoma 2 (BCL2) ELISA kit (CSB-E08854r)

验证数据

CSB-E08854r 标准曲线

货号:CSB-E08854r

规格:96T/48T

灵敏度:0.078 ng/mL

检测范围:0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

BCL2 Antibodies

BCL2 for Mus musculus (Mouse)

BCL2 for Homo sapiens (Human)

BCL2 for H, M, R

BCL2 Proteins

BCL2 Proteins for Gallus gallus (Chicken)

BCL2 Proteins for Homo sapiens (Human)

BCL2 Proteins for Mus musculus (Mouse)

BCL2 Proteins for Rattus norvegicus (Rat)

BCL2 Proteins for Bos taurus (Bovine)

BCL2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

BCL2 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

BCL2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

BCL2 Proteins for Rattus norvegicus (Rat)

BCL2 ELISA Kit

BCL2 ELISA Kit for Homo sapiens (Human)

BCL2 ELISA Kit for Mus musculus (Mouse)

BCL2 ELISA Kit for Rattus norvegicus (Rat)