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Serine-protein kinase ATM is a protein in humans that is encoded by ATM gene. Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes.

ATM Antibodies

ATM for Homo sapiens (Human)

ATM Proteins

ATM Proteins for Homo sapiens (Human)

ATM Proteins for Mus musculus (Mouse)

ATM Proteins for Sus scrofa (Pig)

ATM Proteins for Arabidopsis thaliana (Mouse-ear cress)