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ATF4

ATF4,即激活转录因子4,别名CREB-2。ATF4是一种碱性区域亮氨酸拉链转录因子,属于bZIP家族成员,由人类基因组中的ATF4基因编码。它在细胞对多种应激反应的调控中发挥关键作用,包括氨基酸缺乏、氧化应激和内质网应激等。ATF4的作用机制主要是通过结合到目标基因的启动子区域上的cAMP响应元件(CRE)或相关的DNA序列,调节下游基因的转录。ATF4在生物学上的意义主要体现在其对细胞代谢、存活和应激反应的调控。它参与调节氨基酸代谢、抗氧化反应、蛋白质折叠和损伤修复等过程。在内质网应激时,ATF4能够激活未折叠蛋白反应(UPR),帮助细胞恢复蛋白质稳态。此外,ATF4还参与调节细胞周期、细胞凋亡以及自噬等过程,影响细胞的命运。ATF4的功能异常与多种疾病相关,包括代谢性疾病、神经退行性疾病和某些类型的癌症,因此,它也是药物开发中的一个潜在靶点。

热销产品

Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) (CSB-EP880648RA)

验证数据

CSB-EP880648RA

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ATF4 Antibody (CSB-PA002272KA01HU)

验证数据

CSB-PA002272KA01HU

Western blot analysis of extracts from mouse craniofacial and mouse gastrocnemius, using ATF4 antibody.

CSB-PA002272KA01HU

Immunohistochemistry of paraffin-embedded Breast cancer using ATF4 Antibody.

ATF4 Antibodies

ATF4 for Homo sapiens (Human)

ATF4 Proteins

ATF4 Proteins for Mus musculus (Mouse)

ATF4 Proteins for Homo sapiens (Human)

ATF4 Proteins for Bos taurus (Bovine)

ATF4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

ATF4 Proteins for Rattus norvegicus (Rat)