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Cyclic AMP-dependent transcription factor ATF-2 is a protein in humans that is encoded by ATF2 gene. Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death.

ATF2 Antibodies

ATF2 for Homo sapiens (Human)

ATF2 Proteins

ATF2 Proteins for Rattus norvegicus (Rat)

ATF2 Proteins for Homo sapiens (Human)

ATF2 Proteins for Mus musculus (Mouse)

ATF2 Proteins for Gallus gallus (Chicken)

ATF2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)