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Beta-arrestin-2 is a protein in humans that is encoded by ARRB2 gene. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs).

ARRB2 Antibodies

ARRB2 for Homo sapiens (Human)

ARRB2 Proteins

ARRB2 Proteins for Bos taurus (Bovine)

ARRB2 Proteins for Homo sapiens (Human)

ARRB2 Proteins for Rattus norvegicus (Rat)

ARRB2 Proteins for Pongo abelii (Sumatran orangutan)

ARRB2 Proteins for Mus musculus (Mouse)


ARRB2 ELISA Kit for Rattus norvegicus (Rat)