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Beta-arrestin-1 is a protein in humans that is encoded by ARRB1 gene. Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs).

ARRB1 Antibodies

ARRB1 for Homo sapiens (Human)

ARRB1 Proteins

ARRB1 Proteins for Bos taurus (Bovine)

ARRB1 Proteins for Homo sapiens (Human)

ARRB1 Proteins for Rattus norvegicus (Rat)

ARRB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

ARRB1 Proteins for Mus musculus (Mouse)

ARRB1 Proteins for Oryctolagus cuniculus (Rabbit)