APC
APC,全称为腺瘤性息肉病基因蛋白,是一种重要的肿瘤抑制蛋白。它常见于细胞质和细胞核中,参与多种细胞过程。APC蛋白通过调控β-catenin的稳定性,影响Wnt信号通路,进而调控细胞增殖、分化和凋亡。在正常情况下,APC蛋白能够促进β-catenin的降解,防止其过度积累并进入细胞核,从而抑制靶基因的转录。然而,当APC蛋白发生突变或缺失时,β-catenin会大量积累,激活下游靶基因,导致细胞不受控制地增殖,进而引发肿瘤。
APC蛋白与多种疾病密切相关,尤其是结直肠癌。家族性腺瘤性息肉病(FAP)是一种常染色体显性遗传病,患者体内APC蛋白存在基因突变,导致其功能丧失,极易发展为结直肠癌。此外,APC蛋白的异常也与乳腺癌、卵巢癌等恶性肿瘤的发生发展有关。针对APC蛋白的药物研发已取得一定进展,例如,通过抑制β-catenin的活性,可以阻止肿瘤细胞的生长和扩散。此外,一些靶向APC蛋白的单克隆抗体和抑制剂也正在研发中,有望为结直肠癌等恶性肿瘤的治疗提供新的策略。
热销产品
Recombinant Human Adenomatous polyposis coli protein (APC), partial (CSB-EP001894HU)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
APC Recombinant Monoclonal Antibody (CSB-RA951649A0HU)
验证数据

Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, Rat Brain whole cell lysate
All lanes: APC antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 312, 301, 309 kDa
Observed band size: 160 kDa

IHC image of CSB-RA951649A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
APC Antibodies
APC for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA000897 | APC Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA009252 | Phospho-APC (S2054) Antibody | Human | WB, IHC, ELISA |
CSB-PA009253 | APC Antibody | Human | IHC, ELISA |
CSB-PA010692 | APC Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA589353 | APC Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA951649A0HU | APC Recombinant Monoclonal Antibody | Human, Rat | ELISA, WB, IHC |
APC Proteins
APC Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP001894RA CSB-EP001894RA CSB-BP001894RA CSB-MP001894RA CSB-EP001894RA-B |
Recombinant Rat Adenomatous polyposis coli protein (Apc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
APC Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP001894HU CSB-BP001894HU CSB-MP001894HU CSB-EP001894HU-B |
Recombinant Human Adenomatous polyposis coli protein (APC), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP001894HU | Recombinant Human Adenomatous polyposis coli protein (APC), partial | E.coli |
CSB-EP001894HU | Recombinant Human Adenomatous polyposis coli protein (APC), partial | E.coli |
APC Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP726744MO CSB-BP726744MO CSB-MP726744MO CSB-EP726744MO-B |
Recombinant Mouse Adenomatous polyposis coli protein (Apc), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |