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APC

APC,全称为腺瘤性息肉病基因蛋白,是一种重要的肿瘤抑制蛋白。它常见于细胞质和细胞核中,参与多种细胞过程。APC蛋白通过调控β-catenin的稳定性,影响Wnt信号通路,进而调控细胞增殖、分化和凋亡。在正常情况下,APC蛋白能够促进β-catenin的降解,防止其过度积累并进入细胞核,从而抑制靶基因的转录。然而,当APC蛋白发生突变或缺失时,β-catenin会大量积累,激活下游靶基因,导致细胞不受控制地增殖,进而引发肿瘤。
APC蛋白与多种疾病密切相关,尤其是结直肠癌。家族性腺瘤性息肉病(FAP)是一种常染色体显性遗传病,患者体内APC蛋白存在基因突变,导致其功能丧失,极易发展为结直肠癌。此外,APC蛋白的异常也与乳腺癌、卵巢癌等恶性肿瘤的发生发展有关。针对APC蛋白的药物研发已取得一定进展,例如,通过抑制β-catenin的活性,可以阻止肿瘤细胞的生长和扩散。此外,一些靶向APC蛋白的单克隆抗体和抑制剂也正在研发中,有望为结直肠癌等恶性肿瘤的治疗提供新的策略。

热销产品

Recombinant Human Adenomatous polyposis coli protein (APC), partial (CSB-EP001894HU)

验证数据

CSB-EP001894HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

APC Recombinant Monoclonal Antibody (CSB-RA951649A0HU)

验证数据

CSB-RA951649A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, Rat Brain whole cell lysate
All lanes: APC antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 312, 301, 309 kDa
Observed band size: 160 kDa

CSB-RA951649A0HU

IHC image of CSB-RA951649A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

APC Antibodies

APC for Homo sapiens (Human)

APC Proteins

APC Proteins for Rattus norvegicus (Rat)

APC Proteins for Homo sapiens (Human)

APC Proteins for Mus musculus (Mouse)