ANGPT2
血管生成素-2（ANGPT2），也常见为ANG-2。ANG-2基因定位于染色体的8p23，属于分泌型糖蛋白，分子量大约75kDa。研究表明，ANG-2是ANG-1的天然竞争拮抗剂，两者的受体都是Tie-2。ANG-1与Tie-2结合可激活PI3K/AKT信号通路，维持血管的完整和稳定，抑制肿瘤血管生成。阻滞ANG-1对肿瘤血管系统几乎没有影响，而阻滞ANGPT2却能造成肿瘤血管系统的损伤和Ang-1的活化，使肿瘤血管正常化，抑制肿瘤血管形成。因此，ANGPT2不仅参与了胚胎血管发育、血管重构等正常生理过程，且在肿瘤、创伤、炎症等多种病理过程中发挥了重要作用。目前，ANGPT2已成为免疫检查点和血管生成抑制剂的疗法靶点。
Recombinant Human ANGPT2 活性蛋白实验验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL.
ANGPT2 Antibodies
ANGPT2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA05749A0Rb | ANGPT2 Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-PA05749D0Rb | ANGPT2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA05749B0Rb | ANGPT2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA083784 | ANGPT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA694467 | ANGPT2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA191985A0HU | ANGPT2 Antibody | Human | ELISA, IHC |
| CSB-RA001707MA01HU | ANGPT2 Monoclonal Antibody | Human | ELISA |
ANGPT2 for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA16959D0Rb | Angpt2 Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA16959B0Rb | Angpt2 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA16959A0Rb | Angpt2 Antibody | Mouse | ELISA, WB, IHC |
ANGPT2 Proteins
ANGPT2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001707DO CSB-BP001707DO CSB-EP001707DO-B |
Recombinant Dog Angiopoietin-2(ANGPT2) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001707MO CSB-EP001707MO CSB-BP001707MO CSB-MP001707MO CSB-EP001707MO-B |
Recombinant Mouse Angiopoietin-2(Angpt2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP169594m | Recombinant Mouse Angiopoietin-2(Angpt2),partial | E.coli |
ANGPT2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001707HU | Recombinant Human Angiopoietin-2(ANGPT2),partial | Yeast |
| CSB-EP001707HU | Recombinant Human Angiopoietin-2(ANGPT2),partial | E.coli |
| CSB-BP001707HU CSB-MP001707HU CSB-EP001707HU-B |
Recombinant Human Angiopoietin-2(ANGPT2),partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP001707HU(A4) | Recombinant Human Angiopoietin-2(ANGPT2) (Active) | Mammalian cell |
ANGPT2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001707RA CSB-EP001707RA CSB-MP001707RA CSB-EP001707RA-B |
Recombinant Rat Angiopoietin-2(Angpt2) | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001707BO CSB-EP001707BO CSB-BP001707BO CSB-MP001707BO CSB-EP001707BO-B |
Recombinant Bovine Angiopoietin-2(ANGPT2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP859369PI CSB-EP859369PI CSB-BP859369PI CSB-MP859369PI CSB-EP859369PI-B |
Recombinant Pig Angiopoietin-2(ANGPT2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANGPT2 ELISA Kit
ANGPT2 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04500h | Human Angiopoietin 2,ANG-2 ELISA Kit | serum, plasma, tissue homogenates | 9.75 pg/mL |
ANGPT2 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E07305m | Mouse Angiopoietin 2,ANG-2 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 pg/mL |
ANGPT2 ELISA Kit for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E08460p | Pig Angiopoietin 2,ANG-2 ELISA Kit | serum, plasma, tissue homogenates | 0.235 ng/mL |
ANGPT2 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E07304r | Rat Angiopoietin 2,ANG-2 ELISA Kit |
