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Angiopoietin-1 is a protein in humans that is encoded by ANGPT1 gene. Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades.

ANGPT1 Antibodies

ANGPT1 for Homo sapiens (Human)

ANGPT1 Proteins

ANGPT1 Proteins for Bos taurus (Bovine)

ANGPT1 Proteins for Mus musculus (Mouse)

ANGPT1 Proteins for Rattus norvegicus (Rat)

ANGPT1 Proteins for Homo sapiens (Human)

ANGPT1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ANGPT1 Proteins for Sus scrofa (Pig)


ANGPT1 ELISA Kit for Bos taurus (Bovine)

ANGPT1 ELISA Kit for Mus musculus (Mouse)

ANGPT1 ELISA Kit for Sus scrofa (Pig)

ANGPT1 ELISA Kit for Rattus norvegicus (Rat)