AMBRA1
AMBRA1，即自噬和Beclin 1调节器1，别名DCAF3、WDR94。它是一种由人类基因编码的蛋白，属于自噬调节因子，在自噬体的形成过程中扮演重要角色。AMBRA1的作用机制涉及激活GTPase结合活性和泛素蛋白酶结合活性，参与巨自噬作用、正调节磷酸肌醇3-激酶活性，并响应线粒体去极化。AMBRA1位于细胞质中，并与线粒体共定位，是多系统萎缩的生物标志物。AMBRA1参与控制蛋白周转、神经发育、细胞生存和增殖，与肿瘤进展密切相关，其表达水平预测黑色素瘤对MAPK抑制剂的耐药性，并且与神经管缺陷有关。
热销产品
AMBRA1 Antibody (CSB-PA927593)
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA927593(AMBRA1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA927593(AMBRA1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
AMBRA1 Antibodies
AMBRA1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA001655GA01HU | AMBRA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA883655ESR2HU | AMBRA1 Antibody | Human | ELISA |
| CSB-PA927593 | AMBRA1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA163788 | AMBRA1 Antibody | Human,Mouse | ELISA,IHC |
AMBRA1 Proteins
AMBRA1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001655MO CSB-EP001655MO CSB-BP001655MO CSB-MP001655MO CSB-EP001655MO-B |
Recombinant Mouse Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AMBRA1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP883655HU CSB-EP883655HU CSB-BP883655HU CSB-MP883655HU CSB-EP883655HU-B |
Recombinant Human Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
