AKT3
AKT3,即蛋白激酶Bγ,是蛋白激酶B家族的第三个成员。AKT3主要在大脑、睾丸以及某些类型的癌细胞中表达。其作用机制与AKT1和AKT2类似,通过与PI3K(磷脂酰肌醇3激酶)激活后产生的PIP3结合,被招募到细胞膜上,随后被上游激酶如PDK1磷酸化激活。激活后的AKT3能够磷酸化多种底物,包括促进细胞存活的BAD蛋白、FOXO转录因子以及mTOR信号通路中的组件。AKT3参与的信号通路包括PI3K/AKT/mTOR通路,这一通路在细胞生长、代谢、存活和增殖中起着关键作用。AKT3还与神经发育、突触可塑性以及认知功能相关。在生物学意义上,AKT3对于神经系统的正常功能和发育至关重要。其异常表达或功能失调与多种疾病有关,包括神经退行性疾病、精神疾病和某些类型的癌症。AKT3的活性调节是当前药物开发和疾病治疗研究的热点领域。
热销产品
AKT3 Antibody (CSB-PA15929A0Rb)
验证数据
Immunoprecipitating AKT3 in mouse brain whole cell lysate
Lane 1: Rabbit control IgG (1μg) instead of CSB-PA15929A0Rb in mouse brain whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA15929A0Rb (6μg) + Mouse brain whole cell lysate (500μg)
Lane 3: Mouse brain whole cell lysate (10μg)
AKT3 Antibodies
AKT3 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA001556GA01HU | AKT3 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA000388 | AKT3 Antibody | Human,Mouse,Rat | WB |
CSB-PA983294 | AKT3 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA775649 | AKT3 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA15929A0Rb | AKT3 Antibody | Human, Mouse | ELISA, IP |
CSB-PA15929C0Rb | AKT3 Antibody, FITC conjugated | Human |
AKT3 Proteins
AKT3 Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP723581RA CSB-EP723581RA CSB-BP723581RA CSB-MP723581RA CSB-EP723581RA-B |
Recombinant Rat RAC-gamma serine/threonine-protein kinase (Akt3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKT3 Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP894361MO CSB-EP894361MO CSB-BP894361MO CSB-MP894361MO CSB-EP894361MO-B |
Recombinant Mouse RAC-gamma serine/threonine-protein kinase (Akt3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |