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AKT1

AKT1,即蛋白激酶Bα,是一种在细胞内信号传导中发挥关键作用的丝氨酸/苏氨酸激酶。AKT1广泛存在于多种组织和细胞类型中,是PI3K/AKT信号通路的核心组分。其作用机制是通过PI3K(磷脂酰肌醇3激酶)产生的磷脂酰肌醇-3,4,5-三磷酸(PIP3)的招募,进而被激活。激活后的AKT1能够磷酸化多种底物蛋白,调控细胞的生长、存活、代谢和凋亡等过程。AKT1参与的信号通路包括PI3K/AKT/mTOR通路,这一通路在细胞增殖、蛋白质合成、细胞代谢和细胞存活中起着至关重要的作用。AKT1还与细胞周期调控、细胞应激反应和细胞迁移等过程相关联。在生物学意义上,AKT1对于维持细胞内环境的稳定和适应外界变化至关重要。其功能异常与多种疾病有关,尤其是与肿瘤的发生发展密切相关,是癌症治疗中的一个潜在靶点。

热销产品

Recombinant Rat RAC-alpha serine/threonine-protein kinase (Akt1) (CSB-EP001553RA)

验证数据

CSB-EP001553RA

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

AKT1 Recombinant Monoclonal Antibody (CSB-RA917625A0HU)

验证数据

CSB-RA917625A0HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Raji whole cell lysate, 293 whole cell lysate, Mouse brain tissue, Rat heart tissue
All lanes: AKT1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56 kDa
Observed band size: 56 kDa

CSB-RA917625A0HU

IHC image of CSB-RA917625A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA917625A0HU

Immunofluorescence staining of Hela Cells with CSB-RA917625A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

AKT1 Antibodies

AKT1 for Homo sapiens (Human)

AKT1 Proteins

AKT1 Proteins for Homo sapiens (Human)

AKT1 Proteins for Mus musculus (Mouse)

AKT1 Proteins for Rattus norvegicus (Rat)

AKT1 Proteins for Oryza sativa subsp. indica (Rice)

AKT1 Proteins for Oryza sativa subsp. japonica (Rice)

AKT1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

AKT1 Proteins for Drosophila melanogaster (Fruit fly)

AKT1 Proteins for Xenopus laevis (African clawed frog)

AKT1 ELISA Kit

AKT1 ELISA Kit for Homo sapiens (Human)