Your Good Partner in Biology Research


Disintegrin and metalloproteinase domain-containing protein 17 is a protein in humans that is encoded by ADAM17 gene. Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

ADAM17 Antibodies

ADAM17 for Homo sapiens (Human)

ADAM17 Proteins

ADAM17 Proteins for Homo sapiens (Human)

ADAM17 Proteins for Sus scrofa (Pig)


ADAM17 ELISA Kit for Homo sapiens (Human)

ADAM17 ELISA Kit for Mus musculus (Mouse)