ACHE
ACHE,即乙酰胆碱酯酶,别名AChE,是生物神经传导中的一种关键性酶。它主要来源于生物体内,特别是在胆碱能突触间隙中发挥作用。ACHE的作用机制是通过降解乙酰胆碱(ACh),从而终止神经递质对突触后膜的兴奋作用,保证神经信号在生物体内的正常传递。此外,ACHE还参与细胞的发育和成熟,促进神经元发育和神经再生。ACHE与多种疾病如阿尔兹海默病、肝癌等密切相关。例如,在阿尔兹海默病中,抑制ACHE可以增加ACh的累积,从而缓解认知障碍。而在肝癌中,ACHE的低表达与肝癌细胞的生长和体内成瘤能力有关,提示其作为肝癌预后因子的潜力。
热销产品
Recombinant Human Acetylcholinesterase (ACHE) (CSB-MP001154HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ACHE Antibody (CSB-PA5619A0Rb)
验证数据
IHC image of CSB-PA5619A0Rb diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of MCF-7 cells with CSB-PA5619A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ACHE Antibodies
ACHE for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA001154GA01HU | ACHE Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA547258 | ACHE Antibody | Human | ELISA,WB |
CSB-PA010202 | ACHE Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA010203 | ACHE Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA904467 | ACHE Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA114463 | ACHE Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA5619A0Rb | ACHE Antibody | Human | ELISA, IHC, IF |
CSB-PA5619B0Rb | ACHE Antibody, HRP conjugated | Human | ELISA |
CSB-PA5619C0Rb | ACHE Antibody, FITC conjugated | Human |
ACHE Proteins
ACHE Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP001154HU CSB-BP001154HU CSB-EP001154HU-B |
Recombinant Human Acetylcholinesterase (ACHE) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP001154HU | Recombinant Human Acetylcholinesterase (ACHE) | Mammalian cell |
CSB-MP001154HUd9 | Recombinant Human Acetylcholinesterase(ACHE) | Mammalian cell |
ACHE ELISA Kit
ACHE ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E09670h | Human Acetylcholinesterase,AChE ELISA Kit | serum, plasma, tissue homogenates | 0.23 mU/mL |