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世界白癜风日:儿童、研究与未来的希望

世界白癜风日

世界白癜风日(World Vitiligo Day)设立于每年的6月25日,这一天是为了纪念已故流行音乐天王迈克尔·杰克逊,他的公众形象变化曾引起广泛讨论,但实际上他患有严重的白癜风,这一疾病的误解促使人们设立了这个纪念日,以提高全球对白癜风这一皮肤病的认识、理解与关注。

白癜风(vitiligo)是一种常见的色素脱失性疾病,其特征是皮肤及(或)毛发出现局部或广泛性的白色斑块,这是由于皮肤内的黑色素细胞受损或消失所导致。黑色素细胞负责产生黑色素,这是一种赋予皮肤、眼睛和头发颜色的色素。白癜风可影响所有种族人群,且男女患病率相近,尽管任何年龄都可能发病,但多见于青少年时期。

白癜风的发病机制尚未完全明了,但目前的研究认为其发病涉及遗传、自身免疫、氧化应激、神经因素等多种复杂机制的相互作用。

目前,国内外对于白癜风的研究已经取得了一些重要突破。例如,前期研究发现,白癜风患者中的Nrf2信号通路的活性显著降低,导致黑色素细胞更易受损。Nrf2是机体抵御氧化应激反应的主要调节因子,能够保护过氧化氢诱导的黑素细胞凋亡。因此,激活Nrf2通路成为一种重要的治疗策略。

近年来,白癜风的治疗靶点研究仍在不断拓展,不再局限于JAK抑制剂。研究人员发现IFN-γ对白癜风皮肤黑素细胞具有直接毒性作用,提示人抗IFN-γ单克隆抗体在白癜风治疗中拥有潜在应用价值。此外,国内团队发现抑制MIF可改善白癜风小鼠的疾病进展,有望成为白癫风治疗的新靶点。

华美生物长期致力于为科研工作者提供高质量的蛋白、抗体、ELISA试剂盒等工具类科研试剂产品,鉴于白癜风研究的重要性与迫切性,在此特别整理了一系列与白癜风研究相关的20余种热门靶点及相关试剂产品列举如下,供您选择:

白癜风研究相关ELISA试剂盒:

产品名称 货号 靶点 检测范围 灵敏度
大鼠过氧化氢酶(CAT)酶联免疫试剂盒 CSB-E13439r CAT 93.75 mIU/mL-6000 mIU/mL 23.43 mIU/mL
人过氧化氢酶(CAT)酶联免疫试剂盒 CSB-E13635h CAT 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
小鼠过氧化氢酶(CAT)酶联免疫试剂盒 CSB-E14190m CAT 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
鱼过氧化氢酶(CAT)酶联免疫试剂盒 CSB-E15928Fh CAT 125 mU/mL-2000 mU/mL 62.5 mU/mL
人CD4分子(CD4)酶联免疫试剂盒 CSB-E08956h CD4 0.625 ng/mL-40 ng/mL 0.156 ng/mL
大鼠CD4分子(CD4)酶联免疫试剂盒 CSB-E12928r CD4 0.78 U/mL-50 U/mL 0.195 U/mL
鸡CD4分子(CD4)酶联免疫试剂盒 CSB-E13114C CD4 3.125 ng/mL-800 ng/mL 3.125 ng/mL
人CD8分子(CD8)酶联免疫试剂盒 CSB-E12707h CD8A 62.5 U/mL-4000 U/mL 15.6 U/mL
人细胞毒性T淋巴细胞相关抗原4(CTLA-4/CD152)酶联免疫试剂盒 CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
小鼠细胞毒性T淋巴细胞相关抗原4(CTLA-4/CD152)酶联免疫试剂盒 CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
人干扰素诱导蛋白10(IP-10/CXCL10)酶联免疫试剂盒 CSB-E08181h CXCL10 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
大鼠干扰素诱导蛋白10(IP-10/CXCL10)酶联免疫试剂盒 CSB-E08182r CXCL10 781.25 pg/mL-50000 pg/mL 195 pg/mL
小鼠干扰素诱导蛋白10(IP-10/CXCL10)酶联免疫试剂盒 CSB-E08183m CXCL10 0.312 ng/ml - 20 ng/ml 0.078 ng/ml
猴C-X-C趋化因子10(CXCL10)酶联免疫试剂盒 CSB-EL006240RH CXCL10 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
人白介素8(IL-8/CXCL8)酶联免疫试剂盒 CSB-E04641h CXCL8 31.25 pg/mL-2000 pg/mL 7.110 pg/mL
猪白介素8(IL-8/CXCL8)酶联免疫试剂盒 CSB-E06787p CXCL8 125 pg/mL-8000 pg/mL 31.25 pg/mL
犬白介素8(IL-8/CXCL8)酶联免疫试剂盒 CSB-E08052c CXCL8 0.312 ng/mL-20 ng/mL 0.146 ng/mL
兔子白介素8(IL-8/CXCL8)酶联免疫试剂盒 CSB-E06905Rb CXCL8 23.5 pg/mL-1500 pg/mL 5.8 pg/mL
猴子白介素8(IL-8/CXCL8)酶联免疫试剂盒 CSB-E08051Mo CXCL8 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
牛白介素8(IL-8)酶联免疫试剂盒 CSB-E13052B CXCL8 50 pg/mL-2000 pg/mL 50 pg/mL

白癜风研究相关重组蛋白:

产品名称 货号 靶点 来源 蛋白标签
Recombinant Macaca mulatta Interleukin-10 (IL10) CSB-BP011580MOW IL10 Baculovirus N-terminal 10xHis-tagged and C-terminal myc-tagged
Recombinant Macaca mulatta Interleukin-10 (IL10) CSB-BP011580MOWd7 IL10 Baculovirus C-terminal 10xHis-tagged
Recombinant Human Macrophage migration inhibitory factor (MIF) CSB-BP013826HU MIF Baculovirus N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Rat Transforming growth factor beta-1 proprotein (Tgfb1), partial CSB-BP023446RA Tgfb1 Baculovirus N-terminal 6xHis-tagged
Recombinant Marmota monax Tumor necrosis factor (TNF), partial CSB-BP523593MQG TNF Baculovirus N-terminal 10xHis-tagged
Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial CSB-CF004935HU1 CD4 in vitro E.coli expression system N-terminal 6xHis-tagged
Recombinant Human C-X-C chemokine receptor type 3 (CXCR3) CSB-CF006253HU CXCR3 in vitro E.coli expression system N-terminal 6xHis-tagged
Recombinant Human C-X-C chemokine receptor type 3 (CXCR3) CSB-CF006253HUb0 CXCR3 in vitro E.coli expression system N-terminal 10xHis-tagged
Recombinant Mouse Catalase (Cat) CSB-EP004563MO Cat E.coli N-terminal 10xHis-tagged and C-terminal myc-tagged
Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-EP004966BO CD8A E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human T-cell surface glycoprotein CD8 alpha chain (CD8A), partial CSB-EP004966HU CD8A E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial CSB-EP006163HU1 CTLA4 E.coli N-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial CSB-EP006163MO1 Ctla4 E.coli N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Recombinant Human C-X-C motif chemokine 10 (CXCL10) CSB-EP006240HU CXCL10 E.coli N-terminal 6xHis-tagged
Recombinant Human C-X-C motif chemokine 10 (CXCL10) CSB-EP006240HUc7 CXCL10 E.coli C-terminal 6xHis-tagged
Recombinant Mouse C-X-C motif chemokine 10 (Cxcl10) CSB-EP006240MO Cxcl10 E.coli N-terminal GST-tagged
Recombinant Human C-X-C motif chemokine 9 (Cxcl9) CSB-EP006252HU CXCL9 E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Mouse C-X-C motif chemokine 9 (Cxcl9) CSB-EP006252MO Cxcl9 E.coli N-terminal 6xHis-tagged
Recombinant Rabbit C-X-C motif chemokine (CXCL9) CSB-EP006252RB CXCL9 E.coli N-terminal 6xHis-SUMO-tagged
Recombinant Human C-X-C chemokine receptor type 3 (CXCR3), partial CSB-EP006253HU1 CXCR3 E.coli N-terminal 6xHis-GST-tagged

白癜风研究相关抗体:

● 重组抗体:

产品名称 货号 靶点 反应种属 应用范围
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD8A Recombinant Monoclonal Antibody CSB-RA934881A0HU CD8A Human ELISA, WB, IHC, IP
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
CXCL10 Recombinant Monoclonal Antibody CSB-RA903061A0HU CXCL10 Human ELISA, IHC
IL10 Recombinant Monoclonal Antibody CSB-RA011580A0HU IL10 Human ELISA
IL17A Recombinant Monoclonal Antibody CSB-RA624104MA1HU IL17A Human ELISA
IL6 Recombinant Monoclonal Antibody CSB-RA011664MA1HU IL6 Human ELISA
JAK1 Recombinant Monoclonal Antibody CSB-RA227790A0HU JAK1 Human ELISA, IHC
Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody CSB-RA011931A100phHU JAK2 Human ELISA, WB, IHC, IP
JAK2 Recombinant Monoclonal Antibody CSB-RA267127A0HU JAK2 Human ELISA, IF
JAK3 Recombinant Monoclonal Antibody CSB-RA206737A0HU JAK3 Human ELISA, IHC
MIF Recombinant Monoclonal Antibody CSB-RA146975A0HU MIF Human ELISA, WB
PDCD1 Recombinant Monoclonal Antibody CSB-RA240597A0HU PDCD1 Human ELISA, WB, IHC
TYR Recombinant Monoclonal Antibody CSB-RA567167A0HU TYR Human ELISA, IF

● 单克隆抗体:

产品名称 货号 靶点 反应种属 应用范围
CD4 Monoclonal Antibody CSB-MA000228 CD4 Human,Mouse,Rat ELISA, IHC
CD4 Monoclonal Antibody,Purified CSB-MA783233 CD4 Human ELISA, FC
CD8A Monoclonal Antibody,Purified CSB-MA927984 CD8A Human ELISA, FC
CTLA4 Monoclonal Antibody CSB-MA006163A0m CTLA4 Human ELISA, WB, IHC
CXCL8 Monoclonal Antibody CSB-MA083271A0m CXCL8 Human ELISA, IHC
IFNG Monoclonal Antibody CSB-MA065241A0m IFNG Human ELISA, IHC
IL1B Monoclonal Antibody CSB-MA065741A0m IL1B Human ELISA
IL1B Monoclonal Antibody CSB-MA010884 IL1B Human ELISA, WB, IHC, ICC
IL6 Monoclonal Antibody CSB-MA067571A0m IL6 Human ELISA, WB, IHC
JAK1 Monoclonal Antibody CSB-MA919964 JAK1 Human,Mouse,Rat ELISA, IHC
JAK2 Monoclonal Antibody CSB-MA181103 JAK2 Human,Mouse,Rat ELISA, IHC
JAK2 Monoclonal Antibody CSB-MA780030 JAK2 Human,Mouse,Rat ELISA, IHC
TNF Monoclonal Antibody CSB-MA084771A0m TNF Bovine ELISA
TNF Monoclonal Antibody CSB-MA080271 TNF Human,Mouse,Rat ELISA, WB, IHC
TNF Monoclonal Antibody CSB-MA080272 TNF Human,Mouse,Rat ELISA, WB, IHC

● 多克隆抗体:

产品名称 货号 靶点 反应种属 应用范围
CAT Antibody CSB-PA004980 CAT Human ELISA, WB
Phospho-CAT (Y386) Antibody CSB-PA070042 CAT Human, Mouse, Rat ELISA, WB, IHC
CAT Antibody CSB-PA070043 CAT Human, Mouse, Rat ELISA, IHC
CAT Antibody CSB-PA004563GA01HU CAT Human, Mouse, Rat ELISA, WB, IHC
CAT Antibody CSB-PA599838 CAT Human, Mouse, Rat ELISA, WB, IHC
CAT Antibody CSB-PA942303 CAT Human, Mouse, Rat ELISA, WB, IHC
CD4 Antibody CSB-PA004935ESR2HU CD4 Human ELISA, IHC
Phospho-CD4 (S433) Antibody CSB-PA070257 CD4 Human, Mouse ELISA, IHC, IF
CD4 Antibody CSB-PA001453 CD4 Human, Mouse ELISA, WB, IHC, IF
CD4 Antibody CSB-PA004935GA01HU CD4 Human, Mouse, Rat ELISA, WB
CD8A Antibody CSB-PA004966LA01HU CD8A Human ELISA, IHC
CTLA4 Antibody CSB-PA006163LA01HU CTLA4 Human ELISA, IF
CTLA4 Antibody CSB-PA252417 CTLA4 Human ELISA, IHC
CTLA4 Antibody CSB-PA006163KA01HU CTLA4 Human ELISA, WB, IHC
CTLA4 Antibody CSB-PA224600 CTLA4 Human, Mouse, Rat ELISA, IHC
CXCL10 Antibody CSB-PA06107A0Rb CXCL10 Human ELISA
CXCL10 Antibody CSB-PA822646LA01MOW CXCL10 Macaca mulatta ELISA
CXCL10 Antibody CSB-PA761371 CXCL10 Human ELISA, IHC
CXCL8 Antibody CSB-PA011671YA01DO CXCL8 Dog ELISA
CXCL8 Antibody CSB-PA08327A0Rb CXCL8 Human ELISA, WB, IHC