神经系统疾病
神经系统疾病是指影响大脑、脊髓、周围神经以及其他神经系统组成部分的疾病。这些疾病包括但不限于脑血管疾病、帕金森病、阿尔茨海默病、多发性硬化症、癫痫等。
针对神经系统疾病药物,药物研发的策略包括基于表型的药物发现(PDD)和基于靶点的药物发现(TDD)。PDD通过生物学试验和转化医学标志物来发现具有临床价值的药物,而TDD则侧重于已知靶点的药物开发。不同疾病对应的药物靶点如下:
- 脑血管疾病:血小板聚集、血管紧张素转换酶(ACE)、血管紧张素受体、P2Y12受体等。
- 帕金森病:多巴胺受体、B型单胺氧化酶(MAO-B)、儿茶酚-O-甲基转移酶(COMT)等。
- 阿尔茨海默病:β-淀粉样蛋白(Aβ)、Tau蛋白、乙酰胆碱酯酶(AChE)等。
- 多发性硬化症:S1P受体、干扰素等。
- 癫痫:电压门控钠通道、GABA受体、AMPA受体等。
神经系统疾病药物靶点
- ABCD1
- ACVR2B
- ADCYAP1R1
- ALB
- ANGPT2
- APOE
- APP
- ARSA
- BTX
- C1R
- C1S
- C3
- C5
- C9orf72
- CD19
- CD247
- CD274
- CD276
- CD33
- CD38
- CD3E
- CD4
- CD40
- CD40LG
- CD47
- CD52
- CD80
- CGRP
- CNGA3
- CNGB3
- CNTFR
- CRHR2
- CSF2RA
- CSF3R
- CTLA4
- DAG1
- DAT
- DHPS
- DLG4
- DMD
- DMPK
- DYSF
- EGFR
- EPHA4
- EPOR
- ERBB2
- F10
- F9F9
- FCGRT
- FKRP
- FN1
- FXN
- GAA
- GAG
- GALC
- GBA1
- GDNF
- GHR
- GJB2
- GLP1R
- HEXA
- HEXB
- IDS
- IFNAR1
- IFNB1
- IGF1
- IGF1R
- IGF2R
- IL10
- IL10RA
- IL12A
- IL12B
- IL13RA2
- IL17A
- IL1A
- IL1B
- IL1R1
- IL2
- IL2RA
- IL4R
- IL6R
- IL6ST
- IL7R
- INSR
- LDLR
- MAPT
- MBP
- MECP2
- MS4A1
- MSTN
- MTM1
- MT-ND4
- NGF
- NGFR
- NTRK2
- OTC
- OTOF
- PAH
- PCSK9
- PDCD1
- PGRN
- PLG
- PPT1
- PTCRA
- PYCARD
- RGMA
- RTN4
- SCN1A
- SCN2A
- SELP
- SEMA4D
- SIRT3
- SMN1
- SNAP25
- SNCA
- SORT1
- TARDBP
- TFRC
- TGFB1
- TLR2
- TLR4
- TNF
- TNFSF13
- TNFSF9
- TPP1
- TREM2
- TTR
- UBE3A
- USH2A
- VEGFA
- VWF
神经系统疾病靶点相关产品推荐
● 靶点蛋白
Measured by its binding ability in a functional ELISA. Immobilized Human MAPT at 2 μg/ml can bind Anti-MAPT recombinant antibody (CSB-RA013481A1HU), the EC50 is 4.547-6.284 ng/mL.
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP009514HUb1
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
CSB-MP007479HU
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP004937HU3
Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
● 稳定细胞株
HEK293T/Human SEMA4D Stable Cell Line
CSB-SC835707HU
Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (CSB-RA835707A2HU) (2µg/1*10 6), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA303909A0HU
Overlay histogram showing HepG2 cells stained with CSB-RA303909A0HU (red line) at 1:50.
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA159341A0HU
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
CSB-RA013481MA1HU
Overlay Peak curve showing MCF7 cells stained with CSB-RA013481MA1HU (red line) at 1:100.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ACVR2B Recombinant Monoclonal Antibody | CSB-RA260702A0HU | ACVR2B | Human | ELISA, IHC |
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
APP Recombinant Monoclonal Antibody | CSB-RA994273A0HU | APP | Human, Mouse, Rat | ELISA, WB, IF |
C3 Recombinant Monoclonal Antibody | CSB-RA303909A0HU | C3 | Human | ELISA, WB, IHC, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA699863A0HU | C3 | Human | ELISA, IHC |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CD80 Recombinant Monoclonal Antibody | CSB-RA246383A0HU | CD80 | Human | ELISA, WB, IHC, IP |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human apolipoprotein E (Apo-E) ELISA Kit | CSB-E09748h | APOE | 15.62 ng/mL-1000 ng/mL | 3.9 ng/mL |
Rat apolipoprotein E (Apo-E) ELISA Kit | CSB-E09749r | APOE | 15.6 ng/mL-1000 ng/mL | 15.6 ng/mL |
Mouse apolipoprotein E (Apo-E) ELISA Kit | CSB-E09750m | APOE | 6.25 ng/mL-400 ng/mL | 1.56 ng/mL |
Pig apolipoprotein E (Apo-E) ELISA Kit | CSB-E17889p | APOE | 31.25 ng/mL-2000 ng/mL | 7.81 ng/mL |
Monkey Apolipoprotein E(APOE) ELISA kit | CSB-EL001936RH | APOE | 6.25 ng/mL-400 ng/mL | 1.56 ng/mL |
Rat Amyloid beta A4 protein(APP) ELISA kit | CSB-EL001950RA | APP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |