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Recombinant Mouse G1/S-specific cyclin-D2 (Ccnd2)

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    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

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  • 来源:
    Mammalian cell
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  • 纯度:
    >85% (SDS-PAGE)
  • 基因名:
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  • 别名:
    Ccnd2; Cyl-2; G1/S-specific cyclin-D2
  • 种属:
    Mus musculus (Mouse)
  • 蛋白长度:
    Full length protein
  • 表达区域:
  • 氨基酸序列
  • 蛋白标签:
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.



  • 功能:
    Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
  • 基因功能参考文献:
    1. miR-29b suppressed cellular proliferation and promoted apoptosis of pulmonary artery smooth muscle cells, possibly through the inhibition of Mcl-1 and CCND2. PMID: 29662889
    2. Exercise induced cardiac growth in all of the transgenic mice except for the mice deficient in cyclin D2 PMID: 28901173
    3. we analyzed Cyclin D2(-/-) mice to test whether the ciliary margin zone (CMZ)is a source of retinal cells. Neurogenesis is diminished in Cyclin D2 mutants, leading to a reduction of RGCs in the ventral retina. In line with these findings, in the albino retina, the decreased production of ipsilateral RGCs is correlated with fewer Cyclin D2(+) cells. PMID: 28009286
    4. We showed for the first time that progesterone-induced miR-133a inhibited the proliferation of endometrial epithelial cells by downregulating cyclinD2. PMID: 27458709
    5. cyclin D2 acts as regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. PMID: 27541004
    6. Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin protein) and Ccnd2 (cyclin-D2). PMID: 26868297
    7. miR-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2. PMID: 26818545
    8. NF-kappaB-miR-195/497-Igf1r/Insr-Ccnd2/Ccne1 plays important roles in myogenesis. PMID: 26567220
    9. Loss of N-myc significantly impairs the Sonic hedgehog signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2. PMID: 26238256
    10. Activation of the ERK1/2 signalling pathway, increased phosphorylation of c-myc and significantly increased expression of cyclin D2 protein, are demonstrated. PMID: 25450615
    11. Hippocampus-dependent learning was not generally impaired in Ccnd2 knockout mice, but specifically functional aspects of maze learning were affected. PMID: 24602283
    12. Study reveals molecular insight into how the Ets family transcription factor Pea3 favors EMT and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 target gene. PMID: 23989931
    13. results identify CCND2 as a new key regulator of terminal differentiation in muscle progenitor cells and open new possibilities for the treatment of many forms of muscle disorders characterized by impaired regeneration and loss of muscle mass. PMID: 23612904
    14. Our data suggest that Smoothened signaling, acting through cyclin D2, is critical for the proper development and maturation of the neocortex. PMID: 23680462
    15. This study demonistrated that irradiated wild type and cyclin D2 knockout mice displayed memory deficits one week after acquisition. PMID: 23714078
    16. Cyclin D2 protein expression was increased in islets by day 7, suggesting it may be an early effector driving compensatory beta-cell proliferation in mice eating dietary fats. PMID: 23673159
    17. Cyclin D2 knockout mice with depleted adult neurogenesis were still able to learn the Barnes maze task PMID: 23244288
    18. A novel splice variant of cyclin D2 termed as cycD2SV mediates cell cycle inhibition by sequestering endogenous cell cycle proteins. PMID: 23326442
    19. The data uncover a role for CD2 in the postnatal heart as an effector of GATA4 in myocyte growth and survival. PMID: 22923619
    20. The present study suggests that hippocampal neurogenesis becomes increasingly dependent on cD2 during early postnatal development. PMID: 22564330
    21. This study demonistrated that the morphological abnormalities of the hippocampal formation and/or impairment in adult brain neurogenesis in cD2 KO mice alter their hippocampal-dependent behaviors. PMID: 22101301
    22. these results may indicate that Ccnd2 is involved in central regulation of ethanol intake in mice. PMID: 21429093
    23. found that loss of cyclin D2 actually impairs the whole process of interneuron genesis PMID: 21771816
    24. Major regulator of Ccnd2 expression in pancreatic beta cells is glucose acting via glycolysis and calcium channels; glucose up-regulates nuclear Ccnd2 in quiescent cells and down-regulates Ccnd2 in replicating cells. PMID: 21521747
    25. Results identify a novel Elf5-binding segment upstream of the Ccnd2 gene and demonstrate that Elf5 can transcriptionally repress Ccnd2 by directly binding to the proximal promoter region. PMID: 20831799
    26. CMG-1 participates in the transcriptional regulation of cyclin-D2 via a genomic DNA region between -250 and -216 of the mouse cyclin-D2 gene. PMID: 20545763
    27. D2SV splice variant may play an important role in the postnatal development of these neurons. PMID: 20433897
    28. Cyclin D2 is essential for the expansion of beta-cell mass in response to a spectrum of insulin resistance and points to the cell-cycle protein as a potential therapeutic target that can be harnessed for preventing and curing type 2 diabetes. PMID: 20103709
    29. Cyclin D2 protein stability is regulated in pancreatic beta-cells PMID: 19628581
    30. Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes PMID: 11823472
    31. Decreases in cyclin D2 are partially responsible for the proliferative decline found in aged CD4(+) T cells. A threshold of cyclin D2 may be required for entry into & progression thru the G1 phase. PMID: 12718939
    32. investigated the roles of cyclin D2 in gonadal tumorigenesis and the potential of both p27 and cyclin D2 to act as modifiers of adrenal tumor development in inhibin alpha knockout mice PMID: 12855747
    33. role for cyclin D2, D3, and E, and p27(kip1) proteins in the 4-1BB-mediated cell cycle progression of CD8(+) T cells in vivo PMID: 12884287
    34. cyclin D2 transcription is regulated by the PI3 kinase and Stat5 pathways PMID: 14660677
    35. overexpression of cyclin D2 accelerated myeloid reconstitution following transplantation, and, in agreement with this, cyclin D2-transduced myeloid progenitors showed an enhanced proliferative response to cytokines in vitro PMID: 15105286
    36. cyclin D2 has a role in adult neurogenesis PMID: 15504908
    37. By its compensatory sustained accumulation throughout G(0)-S progression, cyclin D2 can compensate for cyclin D3 loss in cyclin D3-deficient B-1a lymphocytes from D3 mutant mice. PMID: 16818732
    38. Myc is required for a normal hypertrophic response and that its growth-promoting effects are also mediated through a CycD2-dependent pathway. PMID: 16902412
    39. cyclin D3 and cyclin D2 play opposite roles in mouse skin tumor development and that the suppressive activity of cyclin D3 is associated with cyclin D2 downregulation PMID: 16983339
    40. IRS2 knock-out mice presented abnormalities associated with reduced expression of cyclin D2, which indicates dysregulation of key components of the cell cycle apparatus implicated in ovarian function. PMID: 17329594
    41. These results indicate that cyclin D2 translocates p27 from the nucleus into the cytoplasm for its KPC-dependent degradation at the G(0)-G(1) transition. PMID: 17452458
    42. GSK-3beta is a major target of E(2) and P(4) in regulation of cyclin D2 localization in the mouse uterine epithelium. PMID: 17560576
    43. Responsible for neoplastic cell transformation when coexpressed with an activated Ras protein. PMID: 17873913
    44. Selective cortical interneuron and GABA deficits in cyclin D2-null mice. PMID: 17965053
    45. In cyclin D2 transgenic mice cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. PMID: 18079102
    46. essential role for the CycD2-Rb pathway as a governor of cardiac myocyte enlargement in response to biomechanical stress and, more fundamentally, as a regulator of the load-induced activation of RNA pol III PMID: 18420946
    47. These findings establish Cyclin D2 and Cdk4 as direct transcriptional targets of GATA4 and support a model in which GATA4 controls cardiomyocyte proliferation by coordinately regulating numerous cell cycle genes. PMID: 18591257
    48. mTORC1 is a major regulator of beta-cell cycle progression by modulation of cyclin D2, D3, and Cdk4 activity. PMID: 19144649
    49. A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway. PMID: 19401331
    50. This study suggested that adult cyclin D2 knockout brain neurogenesis is not obligatory in learning. PMID: 19553382



  • 亚细胞定位:
    Nucleus. Cytoplasm. Nucleus membrane.
  • 蛋白家族:
    Cyclin family, Cyclin D subfamily
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