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Recombinant Mouse Cytokine receptor-like factor 2 (Crlf2), partial

  • 货号:
    CSB-YP005983MO
  • 规格:
  • 来源:
    Yeast
  • 其他:
  • 货号:
    CSB-EP005983MO
  • 规格:
  • 来源:
    E.coli
  • 其他:
  • 货号:
    CSB-EP005983MO-B
  • 规格:
  • 来源:
    E.coli
  • 共轭:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 货号:
    CSB-BP005983MO
  • 规格:
  • 来源:
    Baculovirus
  • 其他:
  • 货号:
    CSB-MP005983MO
  • 规格:
  • 来源:
    Mammalian cell
  • 其他:

产品详情

  • 纯度:
    >85% (SDS-PAGE)
  • 基因名:
    Crlf2
  • Uniprot No.:
  • 别名:
    Crlf2; Crlm2; Tpte2; TslprCytokine receptor-like factor 2; Cytokine receptor-like molecule 2; CRLM-2; Thymic stromal lymphopoietin protein receptor; TSLP receptor; Type I cytokine receptor delta 1
  • 种属:
    Mus musculus (Mouse)
  • 蛋白长度:
    Partial
  • 蛋白标签:
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

产品评价

靶点详情

  • 功能:
    Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
  • 基因功能参考文献:
    1. A novel mouse xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis has been developed. PMID: 26611474
    2. High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt signal pathway. PMID: 26517374
    3. Activating thymic stromal lymphopoietin promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model. PMID: 25117469
    4. TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells. PMID: 24033709
    5. mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization. PMID: 22385635
    6. Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice. PMID: 22124119
    7. Presence of functional TSLP-specific receptor chain is required for the development of T helper cell type (Th)2 contact hypersensitivity to the hapten fluorescein isothiocyanate (FITC). PMID: 20173025
    8. Induced homodimerization of receptor chimeras containing the transmembrane and cytoplasmic domains of both human and mouse TSLP receptors is not sufficient for driving cell proliferation. PMID: 20096461
    9. expression pattern in antigen presenting cells PMID: 11841846
    10. B-cell development, including the IgM+ compartment, was unaffected by loss of the TSLPR pathway. PMID: 14993294
    11. molecular cloning of Tslpr in insect cells or COS cells resulted in expression of mTSLPR with an extracellular C-terminal end, a surprising result since the N-terminal region contains a signal sequence and two potential glycosylation sites PMID: 15488943
    12. local application of anti-TSLPR prevented Th2-mediated airway inflammation, at least partly, by regulating DCs function, which might be exploited to develop novel treatments for asthma. PMID: 18757241

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  • 亚细胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 蛋白家族:
    Type I cytokine receptor family, Type 5 subfamily
  • 组织特异性:
    High level of expression in liver, lung and testis. Also expressed in heart, brain, spleen, thymus and bone marrow. Highly expressed in progenitors and myeloid cells. Isoform 2 is expressed in primary hemotopoietic cells.
  • 数据库链接: