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CEACAM8 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    CEACAM8重组抗体
  • 货号：
    CSB-RA005168MA1HU
  • 规格：
    ￥1320
  • 图片：
    • The Binding Activity of Human CEACAM8 with Anti-CEACAM8 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM8 (CSB-MP005168HU) at 2 μg/mL can bind Anti-CEACAM8 recombinant antibody, the EC50 is 19.38-21.68 ng/mL.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA005168MA1HU 是靶向人源 CEACAM8 蛋白的重组单克隆抗体，采用小鼠杂交瘤技术制备，具有高亲和力与批次稳定性。CEACAM8 属于癌胚抗原相关细胞黏附分子家族（CEACAM），主要在中性粒细胞表面表达，参与炎症反应调控及病原体识别，其异常表达与慢性炎症性疾病、感染性疾病及免疫调节研究相关。本抗体经 ELISA 验证可特异性识别天然及重组 CEACAM8 蛋白，适用于体外样本中靶蛋白的定性或半定量检测。应用场景涵盖炎症机制研究、免疫细胞功能分析以及相关信号通路探索，可为体外细胞模型、蛋白互作研究或免疫组化实验提供可靠工具，助力科研人员解析 CEACAM8 在免疫应答中的分子作用。
  • Uniprot No.：
    P31997
  • 基因名：
    CEACAM8
  • 别名：
    Carcinoembryonic antigen CGM6 antibody; Carcinoembryonic antigen gene family member 6 antibody; Carcinoembryonic antigen related cell adhesion molecule 8 antibody; Carcinoembryonic antigen-related cell adhesion molecule 8 antibody; CD 66b antibody; CD 67 antibody; CD66b antibody; CD66b antigen antibody; CD67 antibody; CD67 antigen antibody; CEACAM 8 antibody; CEACAM8 antibody; CEAM8_HUMAN antibody; CGM 6 antibody; CGM6 antibody; NCA 95 antibody; NCA95 antibody; Non-specific cross-reacting antigen NCA-95 antibody; Nonspecific cross reacting antigen NCA 95 antibody; Nonspecific cross reacting antigen NCA95 antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human CEACAM8 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG1
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    22H9
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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靶点详情

  • 功能：
    Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
  • 基因功能参考文献：
    1. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
    2. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    3. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
    4. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    5. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
    6. CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 组织特异性：
    Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
  • 数据库链接：

    HGNC: 1820

    OMIM: 615747

    KEGG: hsa:1088

    STRING: 9606.ENSP00000244336

    UniGene: Hs.41

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