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Recombinant Human Claudin-18.2 (CLDN18.2)-VLPs (Active)

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  • 货号:
    CSB-MP005498HU(A5)
  • 规格:
    ¥4000
  • 图片:
    • Western Blot
      CSB-MP005498HU(A5) is detected by Mouse anti-6*His monoclonal antibody.The three bands respectively correspond to monomer, Homodimer, Homotrimer
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml. Biological Activity Assay
    • The presence of VLP-like structures was confirmed by TEM
    • Western Blot
      CSB-MP005498HU(A5) is detected by Anti-Claudin 18 Antibody.The two bands respectively correspond to monomer, Homodimer
  • 其他:

产品详情

  • 内毒素:
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性:
    Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.
  • 基因名:
    CLDN18.2
  • Uniprot No.:
  • 别名:
    CLDN18; UNQ778/PRO1572; Claudin-18
  • 分子结构:
  • 种属:
    Homo sapiens (Human)
  • 蛋白长度:
    Full Length of Isoform A2
  • 来源:
    Mammalian cell
  • 分子量:
    29.1 kDa
  • 表达区域:
    1-261aa
  • 氨基酸序列
    MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
  • 蛋白标签:
    C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
  • 产品提供形式:
    Liquid
    Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
  • 缓冲液:
    PBS, pH 7.4, 6% trehalose
  • 储存条件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • 产品描述:

    This recombinant human claudin-18.2 (CLDN 18.2) is prepared in mammalian cells. Its target gene encodes the full human claudin-18.2 (CLDN 18.2), containing a 10xHis-tag at the C-terminus. The CLDN 18.2 protein has been validated to be active through a functional ELISA. Immobilized human CLDN 18.2 protein can bind to the recombinant anti-CLDN 18.2 monoclonal antibody. And the EC50 is 5.225-9.256 ng/ml. In the WB assay, this CLDN 18.2 protein was detected by the mouse anti-6xHis monoclonal antibody. Three bands appeared on the gel electrophoresis, respectively corresponding to monomer, homodimer, homotrimer of the CLDN 18.2.

    CLDN 18.2, the isoform of CLDN 18, is a tight junction protein exclusively expressed in differentiated epithelial cells of gastric mucosa under normal physiological conditions. Studies have demonstrated that CLDN 18.2 was highly expressed in primary gastric malignancies and post-metastatic types of cancer, including carcinomas of the pancreas, esophagus, ovaries, and lungs. Therefore, CLDN 18.2 has become an ideal target for researchers to develop immunotherapies for solid tumors such as gastric cancer and pancreatic cancer.

  • Datasheet & COA:
    Please contact us to get it.

产品评价

平均分:
5.0分 - 1 个评价

实验应用:药物相关研究

产品评价: 我使用CSB-MP005498HU(A5)产品进行ELISA实验,EC50为7.918-13.26 ng/ml ,蛋白结合活性好。该产品是比较热门的靶蛋白,用于胃癌预测标志物,为我公司研究领域常用蛋白。贵公司产品效果很好,以后还会继续购买。

By 柯老师