NACHT, LRR and PYD domains-containing protein 3 is a protein in humans that is encoded by NLRP3 gene. As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion.

NLRP3 Antibodies

NLRP3 for Mus musculus (Mouse)

NLRP3 for Homo sapiens (Human)

NLRP3 Proteins

NLRP3 Proteins for Bos taurus (Bovine)

NLRP3 Proteins for Macaca mulatta (Rhesus macaque)

NLRP3 Proteins for Homo sapiens (Human)

NLRP3 Proteins for Mus musculus (Mouse)


NLRP3 ELISA Kit for Homo sapiens (Human)

NLRP3 ELISA Kit for Mus musculus (Mouse)