Inhibitor of nuclear factor kappa-B kinase subunit alpha is a protein in humans that is encoded by CHUK gene. Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.

CHUK Antibodies

CHUK Proteins

CHUK Proteins for Homo sapiens (Human)

CHUK Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

CHUK Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

CHUK Proteins for Mus musculus (Mouse)

CHUK Proteins for Gallus gallus (Chicken)

CHUK Proteins for Xenopus laevis (African clawed frog)

CHUK Proteins for Bos taurus (Bovine)