T-cell surface glycoprotein CD3 zeta chain is a protein in humans that is encoded by CD247 gene. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.

CD247 Antibodies

CD247 for Homo sapiens (Human)

CD247 Proteins

CD247 Proteins for Homo sapiens (Human)

CD247 Proteins for Ovis aries (Sheep)

CD247 Proteins for Mus musculus (Mouse)

CD247 Proteins for Oryctolagus cuniculus (Rabbit)

CD247 Proteins for Sus scrofa (Pig)


CD247 ELISA Kit for Homo sapiens (Human)